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Insomnia

19 min read

Restoril vs. Ambien: Comparing Two Sleep Aids

Klarity Editorial Team

Written by Klarity Editorial Team

Published: Dec 21, 2022

Medically Reviewed by Dr. Zoe Russell

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Restoril vs. Ambien: Comparing Two Sleep Aids
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While sleep is essential to your overall well-being, it’s not always easy to come by if you struggle with insomnia. A lack of sleep can contribute to various health concerns and mood changes, so it’s important to seek treatment to get the rest you need. 

With so many treatment options available, it’s hard to know which one will work best for your symptoms. In this article, we’ll discuss Restoril and Ambien, two sleep aids that could help alleviate your insomnia symptoms. 

Licensed providers on Klarity provide personalized treatment. Find a provider that matches your needs and preferences.

If you’re navigating sleeplessness and are looking for insomnia treatment, Klarity can help. Find a licensed provider in your state and have an appointment in as little as 24 hours. No insurance needed.

This article discusses suicide, suicidal ideation, and self-harm. If you or someone you know is experiencing suicidal thoughts or is in crisis, contact the Suicide Prevention Lifeline immediately at 800-273-8255.

AmbienRestoril
Drug ClassSedative-hypnoticBenzodiazepine

Brand / Generic StatusBrand name for zolpidemBrand name for temazepam

Form(s) of the Drug• Immediate-release tablet
• Extended-release tablet
• Nasal spray
• Immediate-release capsule
Standard DosageImmediate-release tablet:
• 5mg
• 10mg

Extended-release tablet:
• 6.25mg
• 12.5mg

Nasal spray:
• 5mg per metered spray

Capsules:
• 7.5 mg
• 15 mg
• 22.5mg
• 30mg
Conditions TreatedFDA-approved uses:
• Insomnia
FDA-approved:
• Insomnia

Off-label:
• Anxiety disorders
• Schizophrenia
• Seizures
• Muscle spasms
CostBrand-name:
• $668 for a 30-day supply

Generic formula:
• $8.30 to $58 for a 30-day supply (with insurance)
• $21.64 per pill (without insurance)
Brand name:
• $180 to $300 for a 30-day supply (less with coupon codes)

Generic (temazepam):
• $6.53 to $13 for a 30-day supply
Side-EffectsCommon side effects:
• Dizziness
Lightheadedness
• Loss of coordination or balance
• Congestion
• Nausea
• Dry mouth
• Constipation
• Diarrhea
• Confusion
• Stomach ache
• Euphoria
• Muscle pain
• Visual changes
• Headaches
• Drowsiness

Serious side effects:
• Memory loss
• Changes in behavior
• Depression
• Anxiety
• Aggression
• Suicidal ideation
• Complex sleep behaviors (Ex. sleep walking/driving)
Common side effects:
• Daytime drowsiness
• Fatigue
• Dizziness
• Loss of coordination
• Headache
• Changes in vision
• Muscle weakness
• Changes in memory
• Increased anxiety or irritability
• GI upset, including nausea, vomiting, abdominal pain, and dry mouth
• Numbness or “pins and needles” sensation on the skin

Serious side effects:
• Changes in mental status
• Confusion
• Hallucinations
• New or worsening anxiety or depression
• Shortness of breath or difficulty breathing
• Suicidal ideation or thoughts of self-harm
Warnings For UseContraindicated conditions:
• Alcohol intoxication
• Depression
• Drug dependence
• Liver disease
• Glaucoma
• Renal dysfunction
• Liver disease
• Respiratory depression

Drug interactions:
• Tramadol
• Ativan
• Clonazepam
• Cymbalta
• Flexeril
• Gabapentin
• Klonopin
• Lexapro
• Lisinopril
• Lyrica
• Trazodone
• Xanax
• Zoloft


Contraindicated conditions:
• Kidney, liver, or lung disease
• History of substance abuse

Drug interactions:
• Other CNS depressants
• Other sleep aids
• Certain antihypertensives
• Neuropathic pain medications
• Psychiatric medications

What is Restoril?

Restoril is also known as Temazepam in its generic form. It’s a prescription medication within the benzodiazepine class of drugs, known for its sedative and calming effects. This medication is often used to treat sleep issues so that you can fall asleep faster and stay asleep longer.  

Restoril Forms and Doses

Restoril is available in both immediate-release and extended-release capsules. The recommended starting dose of Restoril is 7.5 mg for adults, but your care provider may increase or decrease that dose based on your response to the medication and individual needs.

Conditions Restoril Treats

Restoril works by slowing down the central nervous system and is used to treat insomnia or difficulty falling and staying asleep. Because Restoril is a member of the benzodiazepine family, it can have off-label uses for conditions including generalized anxiety, OCD, schizophrenia, muscle spasms, and seizures.

Restoril Costs

The cost of Restoril varies depending on the pharmacy you use and your insurance coverage. It is generally more affordable with insurance, but you can find coupons or discounts online to help reduce the cost. Restoril’s most common generic form can cost anywhere from $39.00 to $227.66 monthly.

Restoril Side Effects

Like all medications, Restoril can cause side effects. Some common side effects of Restoril include:

  • Dizziness
  • Drowsiness during the day
  • Memory issues
  • Loss of coordination
  • Headache
  • Vision problems
  • Muscle weakness
  • Anxiety
  • Irritability
  • Excitability
  • Nausea and vomiting
  • Stomach pain
  • Dry mouth
  • Increased thirst
  • Numbness or tingly feeling

More serious side effects may include confusion, hallucinations, suicidal ideation, anxiety, depression, and difficulty breathing. You should immediately contact your care provider if you experience any side effects.

Restoril Warnings For Use

Before taking Restoril, you should tell your healthcare provider if you have any allergies or medical conditions, such as liver or kidney disease, lung disease, or a history of drug or alcohol abuse. You should also tell your care provider if you are pregnant or breastfeeding, as Restoril may not be safe to take in these situations.

Medication Misuse Warning: Restoril is classified as a Schedule IV controlled substance. Meaning that it is regulated by the government due to its potential for misuse and dependency.

Like other benzodiazepines, Restoril can cause physical and psychological dependence if used for an extended period or at higher doses than prescribed. It is important to take Restoril exactly as directed by your healthcare provider and not exceed the recommended dosage. 

Long-term use of Restoril should be closely monitored, as it’s more intended for short-term usage, and discontinuation should be done gradually under medical supervision to minimize the risk of withdrawal symptoms.

Restoril Interactions

Restoril can interact with other medications, benzodiazepines, opioids, and alcohol. Of the medications most commonly cross-referenced, Restoril has major interactions with Norco and Tramadol. It is important to tell your healthcare provider about all the medicines you are taking before starting Restoril to avoid any potential interactions. 

Moderate interactions occur with the following:

  • Ativan
  • Cymbalta
  • Flexeril
  • Gabapentin
  • Klonopin
  • Lasix
  • Lisinopril
  • Lyrica
  • Neurontin
  • Seroquel
  • Trazodone
  • Xanax
  • Zoloft

What is Ambien?

Ambien, also known as Zolpidem, is a prescription medication within the sedative or hypnotic class of drugs. It works by boosting the chemical gamma-aminobutyric (GABA), which blocks some of the neurotransmitters that send messages to your brain, resulting in a calming effect. 

Ambien Forms and Doses

Ambien is available in two forms: immediate-release and extended-release tablets. The immediate-release tablets help you fall asleep, while the extended-release tablets assist with falling and staying asleep, releasing the medication slowly over time. Your dose varies from 5 to 12.5 mg daily, depending on the form and your care provider’s recommendation.

Conditions Ambien Treats

An effective treatment for insomnia, Ambien helps you fall asleep and stay asleep throughout the night. It can also be prescribed off-label to treat some neurological disorders. 

Ambien Costs

The cost of Ambien depends on the pharmacy you use, the dose you’re prescribed, and your insurance coverage. For the most common form of generic Ambien, you can expect to pay between $8.19 and $42.71. Speak with your provider about taking the generic form of Ambien for more affordable prices. 

Ambien Side Effects

Some common side effects of Ambien include the following.

  • Drowsiness
  • Dizziness
  • Weakness
  • Lightheadedness
  • Fatigue
  • Loss of coordination
  • Congestion
  • Nasal irritation
  • Dry mouth
  • Sore throat
  • Nausea
  • Constipation
  • Diarrhea
  • Stomach pain
  • Headache
  • Muscle pain
  • Confusion
  • Euphoria
  • Visual changes

More serious side effects may include:

  • Hallucinations
  • New or worsening depression
  • Unusual thoughts
  • Suicidal ideation
  • Anxiety
  • Aggression 
  • Difficulty breathing 
  • Complex sleep behaviors (Ex. sleep walking/driving) 

You should contact your care provider immediately if you experience any of these side effects.

Ambien Warnings For Use

Before taking Ambien, you should tell your healthcare provider if you have any allergies or medical conditions, such as liver or kidney disease, lung disease, or a history of drug or alcohol misuse. Additionally, if you experience mental health issues or sleep apnea, it’s important to let your provider know before taking Ambien. 

Medication Misuse Warning: Ambien is classified as a Schedule IV controlled substance. It is subject to strict regulations to prevent misuse and abuse. These regulations ensure that Ambien is prescribed, dispensed, and monitored under specific guidelines.

While its medical benefits are recognized, there is still a risk of dependency associated with the use of Ambien. To avoid this, as well as other negative effects, it is crucial to take Ambien exactly as prescribed by your healthcare provider and only for the recommended duration. 

Abruptly stopping Ambien after long-term use, even though it’s often recommended for short-term use, can result in withdrawal symptoms, so it is important to consult your healthcare provider for a gradual tapering schedule if discontinuing the medication. 

Ambien Interactions

Ambien interacts with 435 drugs, with 28 major interactions, 405 moderate interactions, and two minor interactions. Of the medications most frequently checked, Ambien has major interactions with Tramadol.  

Moderate interactions include:

  • Ativan
  • Clonazepam
  • Cymbalta
  • Flexeril
  • Gabapentin
  • Klonopin
  • Lexapro
  • Lisinopril
  • Lyrica
  • Trazodone
  • Xanax
  • Zoloft

Which Insomnia Medication Should I Take?

Whether you take Restoril, Ambien, or another sleep aid depends on your health history, current symptoms, and your care provider’s recommendation. Both medications can help you fall asleep. If you’re specifically looking to target staying asleep, Ambien might be the better option, as it can reduce the number of times you wake up throughout the night. 

Restoril and Ambien Frequently Asked Questions

Are Restoril and Ambien the same class of drug?

No, Restoril and Ambien are not the same class of drug. Restoril is a benzodiazepine and Ambien is a sedative-hypnotic. 

What’s better for Insomnia? Restoril or Ambien?

The best option for treating insomnia depends on your needs and medical history. Ambien is more effective in helping you fall and stay asleep, but it may not be the right choice for everyone. 

How should Restoril be taken? How should Ambien be taken?

Ambien and Restoril should be taken exactly as prescribed, no more or less, since they can create harmful dependency. These medications should be taken before bed with a full glass of water for the best results. Additionally, if you abruptly stop taking either drug, you could experience withdrawal, so it’s important to taper off with your provider’s guidance.

Can Restoril cause depression? Can Ambien?

Restoril and Ambien can cause a depressed mood, worsen current depression, or contribute to other symptoms of depression. If you are taking Restoril or Ambien and experiencing symptoms of depression, such as a loss of interest in activities you used to enjoy, feelings of hopelessness, or changes in appetite and sleep patterns, speak with your provider.

Can I drive on Restoril or Ambien?

You should not drive while taking Restoril or Ambien, as these medications can cause drowsiness, dizziness, and impaired coordination. Complex sleep behaviors are a serious side effect of Ambien as it can be dangerous for not only the person taking the medication but those around them if, for example, they unknowingly sleepwalk and drive. 

Can I drink alcohol when taking Restoril or Ambien?

Do not drink alcohol while taking Restoril or Ambien. Alcohol can increase the sedative effects of these medications, which can cause excessive drowsiness and increase the risk of other side effects, such as dizziness and difficulty breathing. If you are taking these medications, it’s best to avoid alcohol altogether.

Does it matter what time of day I take Restoril?

Take Restoril and Ambien immediately before bedtime. By taking these medications at the same time each day, you can establish a consistent sleep-wake cycle. You should always follow the instructions of your healthcare provider when taking these medications, as using them at the wrong time of day can increase the risk of adverse side effects.

Start Your Insomnia Treatment Today With Healthcare Providers on Klarity

Getting a good night’s rest shouldn’t be up for debate. Klarity’s telehealth platform allows you to quickly access treatment without the long wait times and inconvenient commutes of a traditional office.

Learn more about insomnia treatment and take a quick self-evaluation to get started with your insomnia treatment today!

Sources:

John P. Cunha. “Restoril” RxList

https://www.rxlist.com/restoril-drug.htm

“Temazepam (RX)” MedScape

https://reference.medscape.com/drug/restoril-temazepam-342911

Sanjai Sinha. “Restoril” Drugs.com

https://www.drugs.com/restoril.html

Ruth Jessen Hickman. “Restoril (Temazepam) – Oral” VerywellHealth

“Restoril” GoodRx

https://www.goodrx.com/restoril?dosage=7.5mg&form=capsule&label_override=temazepam&quantity=30&sort_type=popularity

John P. Cunha. “Restoril Side Effects Center” RxList

https://www.rxlist.com/restoril-side-effects-drug-center.htm

“Restoril Interactions” Drugs.com

https://www.drugs.com/drug-interactions/temazepam,restoril.html

Sanjai Sinha. “Ambien” Drugs.com

https://www.drugs.com/ambien.html

“Zolpidem” NHS

https://www.nhs.uk/medicines/zolpidem/

Femi Aremu. “Zolpidem, Oral Tablet” Healthline

https://www.healthline.com/health/drugs/zolpidem-oral-tablet

Agustin Dominguez Linio. “Off-Label Uses for Zolpidem in Treating Neurologic Disorders” Medical News Bulletin

https://medicalnewsbulletin.com/off-label-zolpidem-neurologic-disorders

“Ambien” GoodRx

https://www.goodrx.com/ambien?dosage=5mg&form=tablet&label_override=zolpidem&quantity=30&sort_type=popularity

John P. Cunha. “Ambien Side Effects Center” RxList

https://www.rxlist.com/ambien-side-effects-drug-center.htm

“Ambien Interactions” Drugs.com

https://www.drugs.com/drug-interactions/zolpidem,ambien.html

Kristi C. Torres. “Restoril vs. Ambien: Differences, similarities, and which is better for you” SingleCare

https://www.singlecare.com/blog/restoril-vs-ambien

IBM Micromedex. “Temazepam (Oral Route)” Mayo Clinic

https://www.mayoclinic.org/drugs-supplements/temazepam-oral-route/side-effects/drg-20072162?p=1

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PO Box 5098 Redwood City, CA 94063

100 Broadway Street, Redwood City CA, 94063

logo
All professional services are provided by independent private practices via the Klarity technology platform. Klarity Health, Inc. does not provide any medical services.
If you’re having an emergency or in emotional distress, here are some resources for immediate help: Emergency: Call 911. National Suicide Prevention Hotline: Call 988. Crisis Text Line: Text Home to 741-741
Fax:
(855) 975-3008

PO Box 5098 Redwood City, CA 94063

100 Broadway Street, Redwood City CA, 94063

If you’re having an emergency or in emotional distress, here are some resources for immediate help: Emergency: Call 911. National Suicide Prevention Hotline: Call 988. Crisis Text Line: Text Home to 741-741
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