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22 min read

Effexor vs. Wellbutrin

Written by Klarity Editorial Team

Published: Nov 17, 2023

Medically Reviewed by Dr. Zoe Russell

Table of contents

Two commonly prescribed options of antidepressant medications are Effexor and Wellbutrin. Living with a mental health condition can feel like navigating through a maze without a map. Adding to this complexity is the challenge of choosing the right prescription medication. This article is designed to act as your guide through the information surrounding these prescription medications.

In this article, we’ll break down essential factors like side effects, conditions treated, dosage guidelines, and potential drug interactions for both Effexor and Wellbutrin. This comprehensive insight will arm you with the information you need to have an informed discussion with your healthcare provider.
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What are the Side Effects of Effexor?

Understanding the side effects of Effexor, known generically as Venlafaxine, is crucial for anyone considering this medication or those already taking it. Effexor is commonly prescribed to treat mental health conditions such as depression, major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder, offering a multi-faceted approach to mental health treatment.

Effexor can be effective in treating a variety of mental health conditions, in addition to off-label use for attention deficit hyperactivity disorder (ADHD). Although, it does come with its own set of drawbacks. Here, we delve into some of the most commonly reported side effects so you’re well-informed before your next consultation with a healthcare provider.


Nausea is one of the most frequently reported side effects of Effexor. It’s particularly common during the initial phase of medication as your body adjusts. Taking the medication with food can help alleviate this symptom. If nausea persists, consult a healthcare provider for alternative solutions, such as changing the time of day you take the medication or adding an anti-nausea drug to your regimen.


Dizziness is often reported by those taking Effexor, especially when moving from a seated or lying position to standing. To mitigate this, it’s recommended to change positions gradually and deliberately. Hydration can also play a key role in reducing episodes of dizziness. In addition, certain over-the-counter medications, such as antihistamines, could worsen the symptom. Paying close attention to your body’s reaction when combining Effexor with other substances can offer valuable information for symptom management.

Dry Mouth

A dry or parched mouth is a common side effect experienced by Effexor users. Sugar-free gum or lozenges can help stimulate saliva production, offering some relief. In extreme cases, artificial saliva substitutes are available over the counter to help alleviate symptoms. Additionally, staying well-hydrated by drinking plenty of water can further combat dry mouth. If the issue persists, speak to a healthcare provider, as chronic dry mouth can lead to dental issues like cavities and gum disease.


Digestive challenges, including constipation, are a known side effect when taking Effexor. To tackle this, increasing fluid intake and making dietary adjustments, such as adding more fibrous fruits, vegetables, and whole grains, can be effective. Some individuals find that regular exercise further aids bowel movements. Over-the-counter laxatives or stool softeners may offer immediate but temporary relief. A symptom diary detailing frequency and severity could provide invaluable insights for future medication or treatment adjustments.


Insomnia is a common side effect associated with Effexor, impacting both your ability to fall asleep and stay asleep. Implementing good sleep hygiene practices, such as adhering to a consistent bedtime and minimizing screen time prior to sleep, can be effective in alleviating this issue. If insomnia persists, you might explore various relaxation techniques or even consider natural sleep aids like melatonin. Some people find that adjusting their Effexor dosage or timing can make a significant difference in sleep quality.

What are the Side Effects of Wellbutrin?

Wellbutrin, also known by its generic name bupropion, is commonly prescribed to treat conditions like depression and Seasonal Affective Disorder (SAD). It’s also used as an aid in smoking cessation programs and is sometimes prescribed off-label for ADHD as it impacts neurotransmitters that are relevant to ADHD symptoms.

Like any medication, Wellbutrin has its own set of side effects that can vary from person to person. Being aware of these potential side effects can help you make an informed decision about your treatment options. Below, we delve into some of the common Wellbutrin side effects that users may experience while taking Wellbutrin.


Vomiting is an unfortunate but possible side effect when initiating Wellbutrin treatment. It tends to be more common in the initial phase as the body adjusts to the new medication. Taking Wellbutrin with food can sometimes reduce the incidence of vomiting. If vomiting becomes severe or persists, it’s important to consult a healthcare provider for proper advice, as prolonged vomiting can lead to dehydration and other health complications.

Stomach Pain

Stomach pain is frequently reported among those taking Wellbutrin, with the intensity varying from mild discomfort to debilitating pain that can interfere with daily activities. Hydration and dietary adjustments, such as avoiding spicy or greasy foods, can help alleviate this discomfort. Additionally, incorporating antacid medications or similar over-the-counter remedies may offer temporary relief. Keeping track of when the pain occurs can provide useful information for potential medication adjustments.


Feelings of agitation or restlessness are commonly reported side effects of Wellbutrin. These sensations can take different forms, including increased anxiety, irritability, or even physical manifestations like tremors or jitteriness. Incorporating physical exercise and relaxation methods like deep breathing or meditation can be beneficial in alleviating these feelings. Keeping a detailed symptom diary can help pinpoint triggers or patterns, providing valuable data for medication adjustments.

Changes in appetite

Appetite changes are a common side effect when taking Wellbutrin, manifesting as either a noticeable increase or decrease in hunger. These shifts can consequently lead to significant weight loss or weight gain. Managing your diet and possibly consulting a nutritionist are effective ways to control these changes. Monitoring caloric intake and maintaining a balanced diet can help mitigate the impact of Wellbutrin on your appetite.

Conditions that Effexor Treats

Effexor is a prescription medication categorized as a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). Effexor primarily affects the levels of serotonin and norepinephrine in the brain, as these neurotransmitters play crucial roles in mood regulation, anxiety control, and overall emotional well-being. By inhibiting serotonin and norepinephrine reuptake, Effexor increases their availability, often leading to improved mood and reduced symptoms of anxiety and depression.

Like many other antidepressant drugs, Effexor has a versatile range of applications. It’s frequently one of the medications of choice for treating various anxiety conditions such as panic disorder and social anxiety. In the following sections, we will delve into these conditions in greater detail, offering insights into how Effexor functions as a treatment option.


Effexor is frequently prescribed for generalized anxiety disorder, a condition characterized by excessive, long-lasting anxiety that is not focused on any one subject or situation. The medication aims to balance neurotransmitters in the brain that impact mood and stress levels. 

Many users report a noticeable decrease in their anxiety symptoms after starting Effexor, although it might take a few weeks for the full effects to be realized. Some individuals also find relief from anxiety-related physical symptoms such as headaches or digestive issues.

Panic Disorder

Panic disorder involves recurrent and unexpected panic attacks that induce intense fear and physical discomfort. Effexor works by stabilizing neurotransmitter levels, reducing the frequency and severity of these attacks for many patients.

The medication can also help diminish anticipatory anxiety—the constant fear of having another panic attack. Cognitive behavioral therapy (CBT) is often used in conjunction with Effexor to treat panic disorder, providing both immediate relief and long-term coping strategies.

Social Anxiety or Phobias

Effexor is often prescribed to treat both social anxiety disorder and specific phobias. For social anxiety, the medication aims to reduce acute feelings of anxiety and fear in social situations, helping individuals feel more at ease and able to engage with others. On the other hand, for those dealing with specific phobias, Effexor can help lower heightened emotional and physical responses, like panic and elevated heart rate.

Both conditions benefit from the medication’s ability to stabilize mood-influencing neurotransmitters. Many patients find that combining Effexor with behavioral therapies provides a more comprehensive approach to managing these mental health conditions.

Depressive Disorders

Effexor is also a potent medication in the fight against depressive disorders. By modulating the neurotransmitters that influence mood, the medication addresses the core neurochemical imbalances underlying depression. Patients with major depressive disorder, dysthymia, or other forms of depression often report improvements in mood, energy, and daily function after incorporating Effexor into their treatment regimen. 

While individual responses can vary, Effexor’s potential to alleviate the pervasive feelings of sadness, hopelessness, and lethargy associated with depression underscores its efficacy in this therapeutic domain.

Conditions that Wellbutrin Treats

Wellbutrin is another prescription medication commonly used to manage various mental and emotional health conditions. Unlike Effexor, which is an SNRI, Wellbutrin is classified as a norepinephrine-dopamine reuptake inhibitor (NDRI). It works by affecting specific neurotransmitters in the brain, including dopamine, which plays a role in mood regulation and reward-driven behavior. Wellbutrin is often considered an effective alternative for those who haven’t had success with other antidepressants.

Wellbutrin has a broad range of applications, making it a multifaceted choice for treating different conditions. While it’s often the first line of defense for issues like depression, it’s also frequently prescribed for smoking cessation and Seasonal Affective Disorder (SAD). Below, we’ll explore these conditions in more detail, discussing how Wellbutrin can be an effective treatment option.


Depression is a mental health condition characterized by persistent feelings of sadness, loss of interest, and a lack of motivation. Wellbutrin is known for its effectiveness in treating these symptoms by enhancing the levels of dopamine in the brain. The result is often a notable improvement in mood and a reduction in feelings of despair or apathy.

Moreover, some users report increased energy levels and focus, making daily activities more manageable. Cognitive behavioral therapy is often recommended alongside Wellbutrin to address underlying thought patterns related to depression.

Smoking Cessation

Wellbutrin is also uniquely qualified as a medication that aids in smoking cessation. It works by affecting neurotransmitters associated with nicotine cravings, thereby reducing the urge to smoke. Many people find that taking Wellbutrin makes the process of quitting more bearable, decreasing withdrawal symptoms such as irritability and anxiety. 

Additionally, unlike nicotine replacement therapies, Wellbutrin offers a non-nicotine approach to quitting, which some individuals prefer. It’s often combined with behavioral strategies to enhance the chances of successfully quitting smoking.

Seasonal Affective Disorder (SAD)

Wellbutrin is one of the few antidepressants that is FDA-approved for the treatment of Seasonal Affective Disorder (SAD), a form of depression that typically occurs during the fall and winter months when daylight is minimal. The medication appears to adjust the circadian rhythm, your internal body clock, by affecting neurotransmitter levels in the brain, specifically dopamine and norepinephrine. This is believed to improve mood and energy levels during the darker months. 

Treatment usually starts in the fall before symptoms begin and continues through the spring. Wellbutrin can be used alone or in combination with light therapy, one of the first-line treatments for SAD. Importantly, the medication doesn’t lead to weight gain, a common concern among those suffering from Seasonal Affective Disorder.

Effexor Dosages

Effexor offers various dosage options to accommodate individual treatment needs. The medication is available in both immediate-release and extended-release forms, also known as Effexor XR. Tailoring the dose depends on a range of factors, including the specific condition being treated, symptom severity, and patient response. Regular consultation with a healthcare professional ensures effective and safe treatment.

  • Effexor Immediate-Release Tablet: Available in 25 mg, 37.5 mg, 50 mg, 75 mg, and 100mg doses. The typical starting dose ranges from 37.5 mg to 75 mg, taken two to three times a day. Dosage may escalate up to a maximum of 375 mg per day based on effectiveness and tolerability.
  • Effexor XR (Extended-Release): Comes in 37.5 mg, 75 mg, and 150 mg capsules. A common starting dose is 75 mg, taken once daily. Depending on the patient’s response, the dose may increase up to a maximum of 225 mg per day. The advantage of the extended-release form is its once-daily dosing schedule.

Wellbutrin Dosages

Wellbutrin, known generically as bupropion, is available in multiple dosage forms, including standard tablets, sustained-release (SR), and extended-release (XL) versions. The appropriate dosage can vary depending on the individual’s medical condition, age, and response to treatment. It’s crucial to work closely with a healthcare provider to determine the most effective dosage regimen.

  • Wellbutrin (Standard Tablet): Available in 75 mg and 100 mg tablets. The typical starting dose is 100 mg, administered twice a day. Dosages can increase up to a daily maximum of 450 mg.
  • Wellbutrin SR (Sustained Release): Comes in 100 mg, 150 mg, and 200 mg tablets. Initial dosages often start at 150 mg, taken once daily in the morning. The dosage may increase to 150 mg twice a day, not to exceed a maximum daily dose of 400 mg.
  • Wellbutrin XL (Extended Release): Available in 150 mg and 300 mg tablets. The common starting dose is 150 mg, taken once in the morning. Dosage can be escalated to 300 mg per day and, in certain cases, up to a maximum of 450 mg per day. The extended-release form permits the convenience of once-daily dosing.

Effexor Drug Interactions

Understanding the possible drug interactions is essential when taking Effexor. The prescription drug can interact with a variety of other medications, affecting their efficacy or increasing the risk of side effects. It’s crucial to provide your healthcare provider with a comprehensive list of all medications, supplements, and herbal products you’re currently using or planning to use.

Here’s more information on the drug interactions associated with Effexor that you should be aware of:


Lithium is a mood stabilizer often prescribed for conditions like bipolar disorder. When used concurrently with Effexor, there’s a heightened risk for serotonin syndrome, a serious and potentially life-threatening condition. 

This is due to both medications increasing serotonin levels, which could lead to an excessive amount of this neurotransmitter in the brain. Symptoms of serotonin syndrome include confusion, rapid heart rate, and high fever. In light of these risks, alternative medication combinations or dose adjustments might be considered.


Tramadol is an opioid-like pain reliever often prescribed for moderate to severe pain. When taken with Effexor, the risk of developing serotonin syndrome increases. This happens because both medications contribute to elevated serotonin levels in the brain. 

Symptoms to watch for include agitation, hallucinations, and rapid heartbeat. Given these potential risks, combining Effexor with Tramadol should be approached with caution, and alternative medication combinations might be explored.


Phenelzine is a Monoamine Oxidase Inhibitor (MAOI) commonly used to treat depression. When used in conjunction with Effexor, it can lead to severe interactions like hypertensive crisis and serotonin syndrome. These serious conditions can manifest as extremely high blood pressure, fever, and even seizures. 

Due to these potentially life-threatening risks, Effexor and phenelzine are contraindicated for simultaneous use. If a transition between the two medications is needed, a “washout” period is usually necessary to safely clear one drug from your system before initiating the other.

Wellbutrin Drug Interactions

When taking Wellbutrin, being aware of potential drug interactions is vital for both efficacy and safety. This NDRI can interact with various medications, which can either boost or decrease its effectiveness or lead to undesirable side effects. Always consult your healthcare provider with a list of all medications you are taking to safely manage potential interactions.

Below is more information on specific drug interactions you should know about when taking or considering taking Wellbutrin:


Efavirenz is an antiretroviral medication primarily used to manage HIV infections. When taken in conjunction with Wellbutrin, efavirenz can induce the liver enzymes responsible for metabolizing Wellbutrin, leading to decreased levels of the drug in your system. 

As a result, the therapeutic effect of Wellbutrin may be diminished. This interaction might necessitate dosage adjustments of Wellbutrin or possibly switching to an alternative medication to achieve the desired therapeutic outcomes.


Metoprolol, commonly prescribed for heart issues and hypertension, can interact with Wellbutrin in a way that increases its blood concentration. This could escalate the risk of experiencing side effects associated with metoprolol, such as hypotension or an excessively slow heartbeat. 

Dosage adjustments of metoprolol or a switch to a different beta-blocker might be considered to avoid these potential complications.


Amantadine is frequently used for the treatment of conditions like Parkinson’s disease or to counter certain types of influenza. When taken alongside Wellbutrin, amantadine’s blood levels may rise, increasing the potential for adverse effects such as nausea, dizziness, or even hallucinations. 

In such instances, adjusting the amantadine dosage or considering alternative medications could be options to optimize treatment outcomes.

Warnings for Effexor Use

Before starting Effexor, it’s important to be aware of the potential risks and warnings associated with this medication. Effexor, like other antidepressants, carries a variety of warnings concerning serotonin syndrome, suicidal thoughts, and other medical conditions. Here are some key warnings to keep in mind:

  • Serotonin Syndrome: Effexor increases serotonin levels, and using it with other substances that do the same can lead to serotonin syndrome, a potentially life-threatening condition.
  • Suicidal Thoughts: Like many antidepressants, Effexor carries a risk of increased suicidal thoughts and behavior, particularly in children, adolescents, and young adults.
  • High Blood Pressure: Effexor has been known to increase blood pressure in some cases, making it crucial for people with hypertension to monitor their levels closely.

Warnings for Wellbutrin Use

Wellbutrin also comes with its own set of warnings and potential side effects that users should be aware of before starting the medication. These include, but are not limited to, risks related to seizures, mental health, and allergic reactions. Here’s what you need to know:

  • Seizure Risk: Wellbutrin can elevate the risk of seizures, especially in individuals with specific medical conditions or those on other medications that diminish the seizure threshold. It is contraindicated in those with alcohol use disorder due to the heightened risk of seizures.
  • Suicidal Thoughts: Wellbutrin also carries a risk of increased suicidal thoughts, particularly among younger users.
  • Hypersensitivity Reactions: Allergic reactions such as skin rash, pruritus, hives, and angioedema have been reported.

How Much Does Effexor Cost?

​​The cost of Effexor can vary depending on factors like location, insurance coverage, and whether you’re purchasing the brand-name or generic version. Generally speaking, the generic version can range from $15 to $50 for a one-month supply, while the brand-name Effexor XR can cost upwards of $100 to $300 for the same supply.

How Much Does Wellbutrin Cost?

Similar to Effexor, the cost of Wellbutrin varies based on several factors. The generic form usually costs between $20 and $60 for a one-month supply. The brand-name version, however, can cost between $200 and $400 for the same amount.

Is Effexor or Wellbutrin More Effective For ADHD Treatment?

Both Effexor and Wellbutrin have shown some effectiveness in treating ADHD symptoms, but they are not first-line treatments and are usually considered when stimulant medications are not suitable or effective. 

Wellbutrin is more commonly prescribed for ADHD as it has a mechanism of action that affects dopamine and norepinephrine, neurotransmitters closely associated with attention and focus. Effexor, primarily considered an antidepressant, has a broader effect on serotonin levels in addition to affecting norepinephrine and is less commonly used for ADHD. 

However, individual responses can vary, and a healthcare provider will consider multiple factors before determining the best treatment option for ADHD.

Schedule an Appointment on Klarity to Learn if Effexor or Wellbutrin is Right For You

Deciding between Effexor and Wellbutrin for treating conditions like depression, anxiety, or other mood disorders can be a complex process that involves weighing numerous factors. From understanding side effects and drug interactions to considering your specific symptoms and health status, a tailored approach is essential. 

With Klarity, you can explore treatment options confidently, knowing you’re in capable hands with licensed providers on their platform. Get personalized recommendations and take the first step toward a more balanced emotional life.

Find a provider on Klarity today to discuss if Effexor or Wellbutrin could be right to treat your mental health condition.



“Effexor vs. Wellbutrin – What Is the Difference?” Rosanna Sutherby, PharmD. WellRx.


“Effexor vs. Wellbutrin: Differences, similarities, and which is better for you.” Kristi C. Torres, Pharm.D. SingleCare.

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