Ambien is the brand name for the generic drug zolpidem. It’s a sedative/hypnotic prescription sleep medication used to treat short-term insomnia.
Is Ambien the answer to your sleep troubles? Find out by talking to an insomnia specialist on Klarity Health in 24 hours or less.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
Ambien (zolpidem) is a non-benzodiazepine sedative-hypnotic drug — also known as a Z-drug. It was U.S. Food and Drug Administration approved for the short-term treatment (7 to 10 days) of adult insomnia due to trouble falling asleep in 1992. It works by slowing down brain activity to make you drowsy during the initial stages of falling asleep so you can fall asleep faster.
Ambien comes in an immediate-release and extended-release (Ambien [CR]) forms. It’s also available as generic zolpidem or zolpidem tartrate. Immediate-release Ambien works quickly to help you fall asleep. Ambien (CR) has 2 layers. The first layer helps you fall asleep faster. The second layer dissolves slowly so you can stay asleep.
Ambien is a Schedule IV controlled substance and has a risk for abuse and dependence.
Ambien is a sedative-hypnotic. It works to sedate you or make you sleepy by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter. Neurotransmitters are chemical messengers that play a role in neurons (nerve cells) communicating in the brain and throughout the body. GABA is the main inhibitory neurotransmitter in the brain, meaning it blocks chemical messages from being passed between cells.
GABA inhibits specific brain signals to reduce activity in the central nervous system (CNS) — basically the brain and spinal cord. By binding to a subtype of GABA receptors, called GABA-A receptors, Ambien helps reduce the excitability of neurons (brain cells), which causes a calming effect on the brain to help you fall asleep.
Ambien is usually prescribed for adults with transient (short-term) insomnia, which is insomnia that lasts 7 to 10 days. It’s basically meant for grown ups who can’t fall asleep. Ambien isn’t intended for long-term use because of its potential for dependency, which is more likely the longer it’s used.
Immediate-release Ambien is best for people who can’t fall asleep.
Ambien CR is for people who can’t fall or stay asleep, also known as having poor sleep maintenance.
You get an Ambien prescription online during a telehealth visit with a trained, licensed healthcare provider, such as a medical doctor (MD), physician assistant/associate (PA), or nurse practitioner (NP). In some states, you’ll need one in-person visit first.
You can discuss insomnia treatment — which may include medication such as Ambien — with a board-certified, licensed provider on Klarity Health.
Once your provider submits your prescription for Ambien to a local or online pharmacy that carries it, you can pick it up or have it delivered to your home.
Learn more about how to get prescribed Ambien.
Immediate-release Ambien and Ambien CR are available as oral tablets. A generic dissolvable sublingual (under the tongue) tablet is also available.
Ambien and generic zolpidem come in 5- and 10-milligram tablets. Ambien CR and generic extended-release zolpidem come in 6.25- and 12.5-milligram tablets. Sublingual zolpidem tartrate is available in 1.75- and 3.5-milligram tablets.
Your provider will typically have you start with the smallest 5-milligram dose. If that dose doesn’t work for you, they may have you increase to the higher dose.
When taking Ambien or Ambien CR, take it when you can get at least 7 to 8 hours of sleep. Swallow the tablet whole with a full glass of water. For the sublingual generic, take it at bedtime or if you wake up during the night and can sleep for at least 4 more hours. Place it under your tongue and let it dissolve before you swallow again.
The most common side effects when taking Ambien are headache, dizziness, and diarrhea. You might also have slowed thinking and motor skills and still be sleepy the next day. You want to avoid driving or operating equipment or machinery until you know how it affects you. And don’t mix Ambien and alcohol or other sedatives or opioids before you talk to your provider.
More serious side effects can happen when taking Ambien too, including allergic reactions, odd thoughts or behaviors, suicidal thoughts and increased depression, trouble breathing, and withdrawal symptoms.
And all products containing zolpidem have a boxed warning, which is the FDA’s most serious warning. The boxed warning is for complex sleep behaviors that can include walking, driving, talking, eating, and other activities while asleep that may result in injury or death.
Immediate-release Ambien costs around up to $130 for 5 tablets using a GoodRx discount and depending on your ZIP code. Ambien CR costs roughly closer to $667 for 30 tablets on GoodRx and with its discount.
Generic Ambien in most forms costs less. And, if using insurance, your copay may be less for generic compared to the brand name. Immediate-release generic zolpidem costs up to $22 for 10 tablets. Generic zolpidem extended-release costs up to $17 for 10 tablets. The sublingual zolpidem tartrate form is most costly at up to $90 for 10 tablets. It’s only available as a generic. Generic costs are from drugs.com and reflect its discount.
If you have insurance that covers Ambien or generic zolpidem, you’ll pay less. You’re also available for the Ambien co-pay card, from Sanofi-Aventis who makes Ambien. With it, you can pay $50 or less for a 30-day supply of immediate-release Ambien.
Coupons from sites like NeedyMeds, GoodRx, drugs.com, SingleCareRx, and Optum can also help you save between 3% to 80% with or without insurance.
Ambien is one of the most common sleep medications prescribed in the U.S., but it’s not the only one. Other popular options include Lunesta (eszopiclone), Sonata (zaleplon), Restoril (temazepam), Silenor (doxepin), Quviviq (daridorexant), Halcion (triazolam), trazodone, and amitriptyline.
Some of these medications are in the same sedative-hypnotic drug class as Ambien. Others are in different classes, such as benzodiazepines, dual orexin receptor antagonists (DORAs), and tricyclic antidepressants (TCAs). Each may work to help you fall asleep and/or stay asleep. Some tend to create a hangover effect where you might still feel drowsy the next day.
Which sleep aid is best for you depends on how well it works for your insomnia. The best way to find out is to talk to a qualified sleep provider who can work with you to create a tailored insomnia treatment.
Learn more about:
Lunesta vs Ambien
Restoril vs Ambien
Restoril vs Ambien
Reviews from real patients who received treatment from providers on Klarity Health.
Providers on Klarity Health are licensed and board-certified. They offer a personalized approach to your unique medical needs. See a detailed profile and services for each provider and find the one best suited for your needs. Providers run their own private practice, and their service options can vary and tailor to your unique needs.
Your journey to better sleep starts with an initial appointment. Your provider will go over your goals and medical history to recommend a treatment plan that’s right for you. Your plan may or may not include prescription medication.
After your initial appointment, you and your provider stay connected to make sure you’re doing okay and reaching your goals. You stay on track with follow-up appointments, medication refills, and ongoing support from your provider. You’re encouraged to regularly check in with your providers.
If you have questions or need assistance, the Klarity Health Patient Support team is here to help. Along with your provider, they’re committed to making sure you have the best care and support possible.
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Ambien.com, Prefer the brand, but worried about elevated costs?, https://www.ambien.com/insurance-coverage
drugs.com Ambien Prices, Coupons, Copay Cards & Patient Assistance, https://www.drugs.com/price-guide/ambien
Dailymed, Label: AMBIEN- zolpidem tartrate tablet, film coated, Aug. 2024, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c36cadf4-65a4-4466-b409-c82020b42452&audience=consumer#section-2.1
Dailymed, Label: AMBIEN CR- zolpidem tartrate tablet, coated, Aug. 2024, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=404c858c-89ac-4c9d-8a96-8702a28e6e76&audience=consumer#section-3
Dailymed,Label: ZOLPIDEM TARTRATE SUBLINGUAL tablet, Oct. 2019, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=44b34e58-114b-4774-9fab-4b188dfe0228&audience=consumer#section-2.1
Frontiers in Psychiatry, Effects of Trazodone on Sleep Quality and Cognitive Function in Arteriosclerotic Cerebral Small Vessel Disease Comorbid With Chronic Insomnia, Jun. 2020, https://doi.org/10.3389/fpsyt.2020.00620
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National Institutes of Health (NIH)/National Cancer Institute, Drug tolerance, https://www.cancer.gov/publications/dictionaries/cancer-terms/def/drug-tolerance
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Springer Link CNS Drugs, Long-Term Safety and Tolerability of Daridorexant in Patients with Insomnia Disorder, Dec. 2022, https://doi.org/10.1007/s40263-022-00980-8
United States Drug Enforcement Administration. (DEA), Drug Scheduling, https://www.dea.gov/drug-information/drug-scheduling#
*Appointments are generally available within 24 hours. Prescriptions, particularly for controlled substances, may require an in-person evaluation depending on the state of residence and current federal regulations.
The information provided in this article is for educational purposes only and should not be construed as medical advice. Controlled substances like Ambien may not be appropriate for all patients and any mention of these medications is for educational purposes only, not for marketing or encouraging self-diagnosis. Always seek the guidance of a qualified healthcare professional with any questions or concerns you have regarding your health. Providers on Klarity Health are independent practitioners with clinical autonomy. Nothing in this article is intended to diagnose or treat any condition, including guaranteeing prescription medication of any kind or dosage.
If you’re having a mental health crisis or experiencing a psychiatric emergency, it’s crucial to seek immediate help from a mental healthcare professional, such as a psychiatrist, psychologist, or therapist. You can also call your local emergency services, visit your nearest emergency room, or contact a crisis hotline, such as the National Suicide Prevention Lifeline, by calling or texting 988 or dialing the Lifeline’s previous phone number, 1-800-273-TALK (1-800-273-8255) in the U.S.
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