With so many drugs on the market for anxiety treatment, finding the right medication for you can seem like a daunting task. In this article, we offer a side-by-side comparison guide for two commonly prescribed medications, Coreg and Zebeta.
We will discuss the major similarities and differences between the two medications so that you can be better informed when discussing treatment options with your healthcare provider.
If you need compassionate, affordable mental health care, let Klarity help! We connect you with a licensed healthcare provider in your local area within 48 hours. Schedule your appointment today so that you can determine which medication, if any, is right for you.
|Drug Class||Beta blocker||Beta blocker|
|Brand / Generic Status||Brand name for carvedilol||Brand name for bisoprolol|
|Form(s) of the Drug||• Extended-release capsules|
• Immediate-release tablets
|• Immediate-release tablet|
|Standard Dosage||Extended-release capsules:|
|Conditions Treated||FDA-approved: |
• Heart failure
• Supraventricular tachycardia (fast heartbeat)
• Arrhythmia (irregular heartbeat)
• Thyrotoxic crisis (thyroid storm)
• Managing the physical symptoms of anxiety
• Heart failure
• Anxiety disorder
|Cost||Brand name: |
• $355 to $427 for a 30-day supply*
• $80 to $203 for a 30-day supply*
*May be less with insurance or discount cards
• Not available for Rx
• $3.78 to $32.94 for a 30-day supply
|Side-Effects||Common side effects:|
• Bradycardia (slow heart rate)
• Postural hypotension
|Common side effects:
• Sleep problems
• Joint pain
• Cold symptoms like a runny or stuffy nose and a sore throat
Serious side effects:
• Shortness of breath
• Rapid weight gain
• Slow heart rate
• Eye pain or vision problems
• Trouble breathing
• Chest tightness
• Pounding heartbeats
• Numbness or tingling in your hands or feet
|Warnings For Use||Contraindicated conditions: |
• Heart rhythm medication
• Other beta blockers
• Blood-pressure medications
• Calcium-channel blockers
• Diabetes medication
• Transplant rejection drugs
Zebeta and Coreg are the Same Class of Drugs (Beta-Blockers)
Zebeta and Coreg are two medications that belong to the same class of drugs called beta-blockers. Although they share a similar mechanism of action, there are some key differences that we will discuss below.
What Are Beta-Blockers?
Beta-blockers are a class of medications prescribed for a wide variety of conditions. They are most commonly used to treat cardiovascular diseases due to their effects on the heart by lowering blood pressure and heart rate. The generic drug names for the majority of beta-blockers typically end with “-olol.”
How Do Beta-Blockers Work?
Beta-blockers work on specific receptors in the body called beta receptors. These receptors are found throughout the body but are most notably in the heart, where they predominantly work. Each beta blocker acts on a different assortment of receptors, including alpha and beta receptors, making each medication unique.
There are two different types of beta-receptors, beta-1 and beta-2, which are found throughout the body and in the heart and in blood vessels.
Beta-1 receptors are primarily found within the heart and kidneys, which are responsible for maintaining our blood pressure and heart rate. When beta-1 receptors are activated, epinephrine is released and signals for the heart to pump faster and harder, causing an increase in blood pressure and heart rate.
Beta-2 receptors are located in the smooth muscle of blood vessels, the nervous system and the respiratory system to also maintain cardiovascular and respiratory balance. When beta-2 receptors are activated, epinephrine signals for changes in vascular tone throughout the body, including the lungs, and increases the workload of the heart.
Beta-blockers act by binding to the receptors to block the effects of a hormone called epinephrine, also known as adrenaline, and therefore slow signaling down. In doing so, the medication primarily works to slow down the heart’s rate and reduce blood pressure, among other actions.
Zebeta is a selective beta-1 receptor antagonist, while Coreg is a beta-1 and beta-2 receptor antagonist. The term antagonist is used to describe the blocking mechanism on the receptor, as described above.
Zebeta and Coreg Can Both Treat the Physical Symptoms of Anxiety
Generalized anxiety disorder is one of the most commonly diagnosed psychiatric conditions known to cause both psychological and physical symptoms. Anxiety is defined as uncontrollable or unwanted thoughts or fears that are not proportional to the given situation. This can appear in many forms, such as panic attacks, social anxiety, PTSD, or generalized anxiety, to name a few.
Some of the most common physical symptoms associated with anxiety include:
- Increased or irregular heart rate
- Increased rate of breathing
- Sweating or hot flashes
- Feeling light-headed or dizzy
- Feeling restless or unable to sit still
- Uneasy feeling in your stomach
What Else Does Zebeta Treat?
Zebeta is most commonly prescribed for cardiovascular conditions but is only FDA-approved for the use of high blood pressure or hypertension. It can be used by itself or in combination with other antihypertensive medications.
Off-label Uses for Zebeta
The term “off-label” is used to describe a medication that has not been FDA-approved. FDA approval requires a large amount of time, funding and resources, which acts as a major barrier to receiving FDA approval. Although a medication is used off-label, this does not mean it is not effective at treating the specific condition.
Some common off-label uses for Zebeta include:
- Physical symptoms of anxiety disorders
- Chest pain
- Atrial fibrillation or flutter
- Heart failure with reduced ejection fraction
- Ventricular arrhythmias
- Prevention of heart attacks or stroke
- Migraine headache prevention
What Else Does Coreg Treat?
Coreg is most commonly used to treat cardiovascular conditions and is FDA-approved to treat:
- High blood pressure
- Mild to severe chronic heart failure
- Left ventricular dysfunction after a heart attack
Off-label Uses for Coreg
As previously mentioned, the term “off-label” simply means that the medication is not FDA-approved for the specific use, and this does not mean it is not effective at treating the given condition.
Some common off-label uses for Coreg include:
- Anxiety disorders
- Heart rate control in those with atrial fibrillation
- Chest pain
- Portal hypertension in people with cirrhosis or liver damage
- Prevention of bleeding in those with esophageal varices or abnormal vein formation due to liver damage
Doses, Dosage Form and Side Effects of Coreg
Common Coreg Doses and Forms
Coreg is available in both name-brand and generic formulations. The generic name for Coreg is Carvedilol. Coreg is available in both tablets and extended-release 24-hour capsules.
The average dose of Coreg varies from person to person, with the average dose around 6.25 mg twice daily. The medication is typically started at a low dose and then titrated up on a weekly basis based on your healthcare provider’s recommendation.
Extended-release 24-hour capsules are available in the following dosages:
- 10 mg
- 20 mg
- 40 mg
- 80 mg
Tablets are available in the following dosages:
- 3.125 mg
- 6.25 mg
- 12.5 mg
- 25 mg
Common Coreg Side Effects
As with most medications, there are associated risks and benefits. Some of those risks include potential side effects after starting Coreg. It is important to remember that everyone reacts to medication differently and to alert your healthcare provider if you experience severe adverse effects when starting a new medication.
Common side effects of Coreg include:
- Dizziness or lightheadedness
- Fatigue or drowsiness
- GI upset, including nausea, vomiting, diarrhea
- Dry eyes
- Sexual dysfunction, including impotence or decreased sex drive
Common Coreg Drug Interactions
There are a few notable drug interactions that occur when taking Coreg. As always, it is important to discuss all current health conditions and current medications you are taking with your healthcare provider.
Some common drug interactions with Coreg include:
- MAO inhibitors
- Certain diabetes medications
- Some blood pressure and antiarrhythmic medications
- Antiviral medications that treat HIV
- Certain anti-nausea medications
- Most opioids
- Asthma or other breathing medications
How Much Does Coreg Cost?
Coreg or Carvedilol is typically covered by most commercial health insurance plans and is often affordable to those without insurance with the use of coupon codes and generic formularies. Coupon codes are available at most large name-brand pharmacies.
The cost of Coreg varies in price depending on generic vs name-brand formularies and dosing. The average cost of a 30-day supply with the use of a coupon code is around $2-6.
Doses, Dosage Form and Side Effects of Zebeta
Common Zebeta Doses and Forms
Zebeta is available in both generic and name-brand formulations. The generic name for Zebeta is bisoprolol fumarate. Zebeta is available in tablet formulations only.
The average dose ranges and varies from person to person, with the average range from 2.5 mg to 20 mg per day. This medication is typically taken once daily and is started at a low dose, which can then be titrated up on a weekly basis until the desired dose is reached.
Zebeta tablets are available in the following dosages:
- 5 mg
- 10 mg
Common Zebeta Side Effects
As previously mentioned, every medication comes with associated risks vs benefits. Some of the risks include the potential for side effects when starting a new medication. It is important to contact your healthcare provider if you begin to experience severe adverse reactions when starting Zebeta.
Some common side effects of Zebeta include:
- Drowsiness or increased fatigue
- Lightheadedness or dizziness upon standing
- Vertigo or spinning sensation
- Dry mouth
- GI upset, including abdominal pain, nausea, vomiting, diarrhea or constipation
- Increased urination
- Difficulty sleeping or insomnia
- Runny or stuffy nose
- Tinnitus or ringing in your ears
- Increased anxiety or feelings of restlessness
- Muscle or joint pain
- Sexual dysfunction, including loss of interest in sex
Common Zebeta Drug Interactions
There are a few drug interactions that should be considered before starting Zebeta. It is important to disclose all medications you are currently taking with your healthcare provider, including over-the-counter medications and supplements.
Common drug interactions with Zebeta include:
- Other blood pressure and antiarrhythmic medications
- Insulin or other diabetic medication
- Asthma or other breathing medication
How Much Does Zebeta Cost?
When compared to Coreg, Zebeta is slightly more expensive but is still relatively affordable. Zebeta is typically covered by most commercial health insurance plans and if you do not have health insurance, coupon codes are available at most large name-brand pharmacies to significantly reduce the cost of the medication.
Similar to Coreg, the cost of Zebeta drastically varies based on dosing and generic vs name-brand formulations. The average cost of a 30-day supply of Zebeta with the use of a coupon code is around $6-10.
Do I Need A Prescription for Zebeta or Coreg?
Yes, you need a prescription for either medication, Zebeta or Coreg. Schedule an appointment today on Klarity, and we will connect you with a licensed healthcare provider in your area.
Beta Blocker Drug Warnings
It is important to take your medication as prescribed by your healthcare provider. If you are considering stopping the medication, notify your provider, as you will likely need to be tapered off. If you discontinue the medication abruptly, you are more likely to experience adverse effects, such as dangerous increases in blood pressure.
Pregnancy and Breastfeeding on Beta-Blockers
While beta-blockers are typically considered relatively safe for use during pregnancy and breastfeeding, there should always be caution while using beta-blockers in pregnancy. Beta-blockers are considered to be a first-line medication for hypertension during pregnancy but have been shown to cause low heart rate and low blood glucose levels in the fetus.
It is important to monitor fetal growth throughout pregnancy and 48 hours after delivery when taking beta-blockers. Some of the most common findings include low heart rate, low blood sugar, and depressed respiratory drive in the newborn.
Treating maternal hypertension typically outweighs the adverse effects, as chronic high blood pressure throughout birth can be unhealthy. If the medication is used solely for the purpose of reducing physical symptoms of anxiety during pregnancy, discuss this with your healthcare provider, as a different medication may be a better option for you.
Klarity Will Help You Find Effective, Non-Habit-Forming Anxiety Medication Alternatives Online
If you are struggling with physical symptoms associated with anxiety, you are not alone, and we can help. Providers on Klarity can provide the correct diagnosis and individualized treatment plan that will work best for you.
At Klarity, we connect you with a healthcare provider in your area in as little as 48 hours. No insurance or subscriptions necessary, and most importantly, no hidden costs. Schedule an appointment to get started today.
Licensed providers on Klarity provide personalized mental health treatment. Find a provider that matches your needs and preferences.
Coreg and Zebeta Frequently Asked Questions
We went over a lot of information and understand that navigating through your different treatment options can be challenging. Below we have listed some of the most commonly asked questions about Coreg and Zebeta.
What is Coreg?
Coreg is a beta-1 and beta-2 receptor blocker that can help treat various cardiovascular conditions, most notably hypertension and chronic heart failure. Coreg is also known to be effective in the treatment of the physical symptoms of anxiety.
What is Zebeta?
Similar to Coreg, Zebeta is another beta blocker medication that is primarily used for the treatment of high blood pressure but is also effective in the treatment of the physical symptoms associated with anxiety. Zebeta is a selective beta-1 receptor antagonist.
Are Coreg, Zebeta, and other Beta-Blockers the same drug?
Although Coreg and Zebeta belong to the same class of medications, called beta-blockers, they are not the same drug. They share a similar mechanism of action, but they have key differences.
What’s better for anxiety? Coreg or Zebeta?
Overall, beta-blockers are not considered a first-line treatment for anxiety, as there are other medications that are more effective and are FDA-approved for the treatment of anxiety.
When comparing Coreg and Zebeta, they are typically seen as equally effective with regard to treating anxiety. Of note, the most effective beta blocker for anxiety is propranolol or Inderal.
Can I drink alcohol on Coreg or Zebeta?
It is generally recommended to avoid drinking alcohol while taking a beta-blocker due to changes in blood pressure. Alcohol consumption while taking a beta-blocker can cause your blood pressure to rise and fall, which increases the risk of fainting, falling or other injuries.
Does it matter what time of day I take Coreg or Zebeta?
It is important to take the medication as prescribed by your healthcare provider, including the dosage and the time of day. Typically, Coreg is taken twice a day, and Zebeta is taken once daily.
The medication is usually taken during the day when you are more likely to have symptoms, but your prescribing provider will instruct you on when to take your medication specifically.
“Bisoprolol Fumarate Coupons & Prices”. SingleCare. https://www.singlecare.com/prescription/bisoprolol-fumarate?q=Bisoprolol%20Fumarate
“Bisoprolol: Drug information” UpToDate. https://www.uptodate.com/contents/bisoprolol-drug-information?search=zebeta&source=search_result&selectedTitle=1~42&usage_type=panel&kp_tab=drug_general&display_rank=1
“Carvedilol Coupons & Prices” SingleCare. https://www.singlecare.com/prescription/carvedilol
“Carvedilol: Drug information” UpToDate. https://www.uptodate.com/contents/carvedilol-drug-information?search=coreg%20&source=search_result&selectedTitle=1~65&usage_type=panel&kp_tab=drug_general&display_rank=1
John P. Cunha, DO. “Coreg vs. Zebeta” RxList. https://www.rxlist.com/coreg_vs_zebeta/drugs-condition.htm