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Weight Loss

16 min read

Ozempic vs Wegovy – everything you need to know

Written by Brittney Bertagna

Published: Jan 11, 2024

Medically Reviewed by Dr. Kasra Tayebi

Table of contents

Are you considering medication-assisted weight loss or weight management? If so, you may be overwhelmed by the amount of information available. In this article, we compare Ozempic vs Wegovy to help you make an informed decision, whether you’re just starting your weight loss journey or looking for alternative options.

Ozempic and Wegovy are both medications used for weight management. They belong to a class of drugs called GLP-1 (glucagen-like peptide 1) receptor agonists. These medications work by mimicking the action of a hormone in the body called GLP-1, which helps regulate blood sugar levels and appetite.

Get a prescription for Ozempic or Wegovy in as little as 24 hours.

At Klarity, we can connect you with independent healthcare providers for weight loss who can prescribe weight loss injections and help you on your weight loss journey. 

Let’s dive into the details and explore the similarities and differences between Ozempic and Wegovy.

Are Ozempic and Wegovy the same?

Ozempic and Wegovy are different formulas of the same GLP-1 receptor agonist used for weight management. semaglutide. Both are taken as a once-a-week injection. 

Both medications lower blood sugar levels and suppress appetite to promote weight loss.

Wegovy vs Ozempic: what’s the difference?

While similar, Wegovy and Ozempic are approved for different users/patient populations.


Ozempic is approved by the Food and Drug Administration (FDA) to manage blood sugar levels in individuals with type 2 diabetes. It may promote weight loss but isn’t approved for weight management.

It has, though, gained popularity for off-label use for weight loss management. According to the prescribing information for Ozempic, it’s indicated for use as an adjunct to diet and exercise for balancing blood sugar levels in individuals with type 2 diabetes. Additionally, it can reduce the risk of heart attacks and strokes in type 2 diabetics.


Wegovy is FDA-approved for weight management in individuals who are medically obese (have a body mass index [BMI] of 30 or higher). It has also been approved for individuals who are overweight (have a BMI of 27 or higher) and have an additional cardiometabolic condition, such as high blood pressure or type 2 diabetes.

Ozempic and Wegovy: a comparison

Indications of useBlood sugar management in individuals with type 2 diabetes.Weight management in individuals with a BMI of 30 or higher or a BMI of 27 or higher with additional medical conditions.

Improved blood sugar control. Weight loss is common. Significant weight loss, improved blood sugar control, reduced risk of weight-related medical conditions.
Side effectsGastrointestinal discomfort or distress, changes in vision, allergic reactionGastrointestinal discomfort or distress, changes in vision, allergic reaction
RouteOnce a week injectionOnce a week injection
Price$900–$1,000 a month$1,300$1,400 a month

It’s important to note that the above chart isn’t intended to replace the advice of a medical professional. Each person’s needs should be discussed with their healthcare provider to determine the best course of treatment.

Ozempic vs Wegovy for weight loss: which one is better?

When it comes to Wegovy vs Ozempic for weight loss, it depends on your individual needs and circumstances. Studies have shown that individuals who are overweight or obese who were treated with semaglutide lost up to 15% of their weight in a 6 month period. 

If you have type 2 diabetes and are looking to improve blood sugar control, Ozempic may be the best option for you. On the other hand, if you don’t have diabetes but want to lose weight, Wegovy may be more appropriate.

Ultimately, the decision should be made in consultation with a healthcare professional who considers your medical history, current health status, and weight loss goals. They can provide personalized recommendations and guide you toward the medication that’s most likely to be effective and safe for you.

Whether your provider recommends Ozempic, Wegovy, or another option, be sure to discuss and understand the potential side effects of any medication you take.

Discover a tailored approach to weight loss that fits your unique needs.

What are the benefits and side effects of Wegovy vs Ozempic for weight loss?

When considering the benefits and potential side effects of Ozempic and Wegovy, it’s important to keep in mind that these medications are prescribed for different purposes. Here’s a breakdown of the benefits and typical side effects of each medication.

Benefits of Ozempic

Blood sugar control: Ozempic can help lower and control blood sugar levels in individuals with type 2 diabetes. This can lead to better management of the condition and potentially reduce the risk of complications associated with high blood sugar.

Weight loss: While not its primary indication, according to Healthline, Ozempic has been associated with weight loss in individuals with type 2 diabetes.

Benefits of Wegovy

Weight loss: Wegovy is specifically indicated for weight management in individuals who are medically obese or overweight. According to a 2022 paper, it’s been shown to help individuals achieve significant weight loss when used as part of a comprehensive weight management plan.

Side effects of Ozempic and Wegovy (semaglutide)

Because Ozempic and Wegovy are both variations of semaglutide, side effects are often similar, but individual responses can vary. 

Mild side effects associated with semaglutide

Gastrointestinal distress: Some individuals experience nausea, vomiting, diarrhea, or stomach pain as side effects of semaglutide. These side effects are usually mild and tend to diminish with continued use.

Hypoglycemia (low blood sugar): While rare, there is a risk of low blood sugar when using Ozempic or Wegovy. This is more likely to occur if the medication is used in combination with other blood sugar-lowering medications.

Severe side effects associated with semaglutide

Pancreas and gallbladder: According to research on the safety of semaglutide, severe but rare side effects include pancreatitis (pancreatic inflammation) and gallbladder complications, such as gallstones.

Risk of thyroid cancer: The active ingredient in both medications is shown to increase the risk of thyroid cancer in animal studies but there’s no evidence it causes cancer in humans 

Between Ozempic and Wegovy, which should you take? 

You and your doctor want to consider many factors when choosing between Ozempic and Wegovy, including medical history, symptoms, and potential side effects. It’s also important to consider economic factors when making the decision since both medications have a high retail price.

Who may benefit from taking Ozempic or Wegovy?

For individuals struggling with weight loss, despite making diet and lifestyle changes, Ozempic or Wegovy may help. Additionally, individuals with type 2 diabetes who want a once-weekly medication to help manage blood sugar levels may also benefit from Ozempic. For those without type 2 diabetes but struggling to lose weight, Wegovy, and the off-label use of Ozempic for weight loss, could be the answer. 

Consult with your healthcare provider to determine the right weight-loss plan for you.

Who shouldn’t take these drugs?

While Ozempic and Wegovy can be beneficial for many individuals, there are some people who shouldn’t take these medications. It’s important to consult with a healthcare provider to determine if these drugs are suitable for you. 

Here are some factors that may make someone ineligible for taking Ozempic or Wegovy.

Allergy or hypersensitivity: If you have a known allergy or hypersensitivity to semaglutide (the active ingredient in Ozempic) or any component of Wegovy, it’s important to avoid these medications.

Type 1 diabetes: Ozempic and Wegovy are not indicated for the treatment of type 1 diabetes. These medications are specifically approved for individuals with type 2 diabetes or weight management in individuals who are overweight. 

If you have type 1 diabetes, speak with a healthcare professional before starting any medication.

What to consider before taking Wegovy or Ozempic

It’s important to be aware of the potential risks and benefits associated with any medication before taking it. It’s also important to consider individual and economic factors when determining which medication is right for you.

Ozempic vs Wegovy cost

There are several factors that can affect the price you pay for Ozempic or Wegovy, such as your location, dosage, and the pharmacy you visit. Obtaining a prescription for either medication requires an appointment with a healthcare professional. 

Both medications come with a steep price tag. Ozempic prices are often up to $1,000 a month, while Wegovy prices can cost as much as $1,400. 

Health insurance may cover some or all of the cost of your medication. Check with your insurance provider to understand your coverage details, including any co-pays or deductibles you’re required to pay. Know that many insurance carriers don’t cover off-label medications.

Using Ozempic or Wegovy for weight loss

If you’re looking for help with weight loss, Klarity can help you find an independent, qualified healthcare provider to work with you on your weight loss goals. Find a provider today and get the support you deserve.

FAQs about Wegovy vs Ozempic

Which is better for weight loss, Ozempic or Wegovy?

When comparing medications for weight loss, it’s important to consult a healthcare provider. While Ozempic can reduce weight and Wegovy is FDA-approved for weight management, individual responses may vary. Seek personalized advice from a healthcare provider to determine the best option for you.

Can you replace Ozempic with Wegovy?

No. Ozempic and Wegovy aren’t interchangeable. While both medications belong to the same class of drugs called GLP-1 receptor agonists, they have different approved indications and dosing regimens. Ozempic comes in 0.25 mg, 0.5 mg, 1 mg, and a 2 mg dose, with a maximum dose of 2 mg per week. Wegovy comes in 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg doses. Dosages start with the small doseand are increased over time to the highest or second-highest does. Your provider will help you with the dosing regimen and right upper dose for you.

How much weight can you lose in a month with Wegovy vs Ozempic?

Individual weight loss results vary when using Wegovy and Ozempic. While both medications can promote weight loss, the amount of weight you may lose in a month depends on several factors and can differ for each person. 

It’s advisable to consult with a healthcare provider for personalized guidance on potential weight loss outcomes.

What alternatives are available for Ozempic and Wegovy? 

If you’re exploring alternatives to Ozempic and Wegovy for weight management, a few options are available. Your healthcare provider can discuss other medications within the GLP-1 receptor agonist class that may be suitable for you. Additionally, other approaches, such as lifestyle modifications, diet plans, and exercise guidance, can also be effective. 

It’s important to consult a healthcare provider to determine the best alternatives for your specific needs, whether medically supervised weight loss or another option.

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