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Mydayis vs Adderall: which ADHD medication should I take?

Written by Klarity Editorial Team

Published: Apr 18, 2024

Medically Reviewed by Dr. Zoe Russell

Table of contents

Which medication is the best for your attention deficit hyperactivity disorder (ADHD)? The answer depends on different factors — from what kind of ADHD you have to your medical history. This is especially true when assessing similar medications like Mydayis vs Adderall. 

The comparison guide here includes comprehensive information on each medication and explains their similarities and differences, cost, and contraindicated conditions. This will help you work with your healthcare provider to choose the best medication to manage your ADHD. 

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Mydayis vs Adderall: the difference

When comparing Mydayis vs Adderall, it’s essential to understand the features that set each ADHD medication apart in terms of formulation, duration of action, and potential benefits for your ADHD treatment

Mydayis (amphetamine/dextroamphetamine) is a single-entity amphetamine product designed to provide extended-release relief for up to 16 hours. It offers a longer duration of action compared to traditional formulations of Adderall (amphetamine/dextroamphetamine).

In contrast, Adderall is available in both immediate-release and extended-release formulations. The immediate-release version typically lasts 4 to 6 hours, while the extended-release version (Adderall XR) provides symptom relief for up to 12 hours.

Mydayis and Adderall are classified as central nervous system stimulants and share similar mechanisms of action in targeting neurotransmitters implicated in ADHD, such as dopamine and norepinephrine. They may, though, exhibit differences in their side effect profiles and tolerability. Understanding these nuances and ADHD statistics is important when selecting the most appropriate ADHD medication, as factors such as comorbid medical conditions, medication preferences, and treatment goals may influence treatment decisions.

What is Mydayis?

Mydayis is an amphetamine-based ADHD medication that works by targeting neurotransmitters in the brain that control things like hyperactivity, impulsivity, and issues with focus. Like Adderall, it’s a central nervous system stimulant. 

Forms and dosages of Mydayis

Mydayis capsules begin at a dosage of 12.5 milligrams. Depending on your needs, dosages can be increased to 25 milligrams, 37.5 milligrams, and 50 milligrams. Mydayis capsules are designed to disburse a steady stream of medication into the bloodstream over a 16-hour period. 

Conditions treated by Mydayis

Mydayis is primarily used to treat ADHD, but it can be used off-label to treat narcolepsy and other sleep disorders.

Costs of generic and brand name Mydayis

Mydayis comes in generic and branded forms. Out-of-pocket costs without insurance are approximately $350 to $400 for a 1-month (30-day) supply of 12.5-milligram tablets. The price for a generic supply of the medication is cheaper, as both SpecGX and Sun received U.S. Food and Drug Administration (FDA) approval for generic forms of Mydayis in August and September 2023.

For accurate pricing under your health insurance, contact your provider’s pharmacy department.

Side effects of Mydayis for adults with ADHD

Side effects of Mydayis treatment in adults include but aren’t limited to:

  • Insomnia
  • Decreased appetite
  • Weight loss
  • Dry mouth
  • Elevated heart rate
  • Anxiety

The more severe but rare side effects of Mydayis include:

  • Seizures
  • Exacerbated heart rate or mental problems

For more information on side effects, warnings, and drug interactions, speak with a healthcare provider who can explain the benefits and drawbacks of using an ADHD stimulant medication like Mydayis. If you experience any serious or life-threatening side effects, seek emergency medical care immediately. 

Warnings and drug interactions when taking Mydayis for ADHD treatment

When considering Mydayis for ADHD treatment, it’s important to be aware of potential warnings and drug interactions. Mydayis, an extended-release medication, can significantly impact the cardiovascular system. Monitoring blood pressure and heart rate is critical, especially if you have a pre-existing heart condition. Psychological side effects, including increased anxiety, mood swings, and, in some cases, psychotic symptoms, may also occur.

Mydayis can interact with several types of medications. It’s vital to inform your healthcare provider of all drugs you’re taking. Key interactions include:

  • Antidepressants: Monoamine oxidase inhibitors (MAOIs) such as isocarboxazid, selegiline, SSRIs (selective serotonin reuptake inhibitors) such as sertraline and citalopram, and SNRIs (serotonin and norepinephrine reuptake inhibitors) like Venlafaxine, can interact with Mydayis.
  • Blood pressure medications: Calcium channel blockers like amlodipine and diuretics such as hydrochlorothiazide may have reduced efficacy with Mydayis.
  • Acidifying agents: Citric acid (found in citrus fruits) and cranberry juice can decrease the absorption of Mydayis.
  • Alkalinizing agents: Agents like potassium citrate and antacids, such as calcium carbonate, can increase the absorption of Mydayis, possibly leading to higher blood levels and effects.

Always consult with a healthcare professional before starting or changing your Mydayis regimen and if you start other medications.

What is Adderall?

Adderall is a central nervous system stimulant composed of 2 medications: amphetamine and dextroamphetamine. These ingredients work by targeting neurotransmitters in the brain, like dopamine and serotonin. By altering the behavior of certain neurotransmitters, Adderall effectively manages ADHD symptoms, like hyperactivity, impulsivity, and lack of attention and focus.

Adderall comes in 2 forms: Adderall IR and Adderall XR. Adderall IR is an immediate-release medication that treats symptoms for about 5 to 8 hours. Adderall XR, on the other hand, is an extended-release medication that helps alleviate symptoms of ADHD for 10 to 12 hours. 

Forms and dosages of Adderall

Adderall comes in tables with 5 milligrams, 7.5 milligrams, 10 milligrams, 12.5 milligrams, 15 milligrams, 20 milligrams, and 30 milligrams. Adderall is in generic form and can be in either an immediate-release tablet (IR) or extended-release (XR) formula that lasts up to 12 hours per capsule. 

Adderall IR is taken 1 to 2 times per day, depending on your needs. The last dose of the day shouldn’t be taken after 12 p.m. to avoid losing sleep or experiencing restlessness. 

Conditions treated by Adderall

Adderall is approved by the FDA to combat ADHD and narcolepsy.

Costs of generic Adderall

Adderall is available in a generic form, which is much less expensive than brand-name Adderall. Without insurance, you can expect to pay around $12 daily for 5 milligrams of generic Adderall. With health insurance, you’re likely to pay no more than $30 for a 1-month supply of 5 milligrams of generic Adderall. For accurate pricing information, contact your healthcare provider’s pharmacy department and ask for your insurance tier’s specific pricing. 

Side effects of Adderall for ADHD

Most stimulants carry risks and should be avoided if you’re suffering from anxiety, heart issues, and circulation issues. The following are potential side effects of taking Adderall:

  • Irregular heartbeat
  • Elevated heart rate
  • Increased blood pressure
  • Restlessness
  • Dry mouth
  • Diarrhea, constipation, nausea
  • Headache
  • Weight loss
  • Mood changes
  • Anxiety
  • Dizziness

More severe but less common Adderall side effects include:

  • Seizures
  • Eyesight instability
  • Urinary tract infection
  • Nausea
  • Fever
  • Stroke
  • Heart attack

Warnings and drug interactions when taking Adderall for ADHD

When considering Adderall for ADHD treatment, it’s important to be aware of potential warnings and drug interactions. Adderall can have significant effects on the cardiovascular system, making it essential to monitor blood pressure and heart rate, especially if you have a pre-existing heart condition. There’s also a risk of developing psychological side effects, such as increased anxiety, mood swings, and, in rare cases, psychotic symptoms.

Adderall can interact with several types of medications, so it’s important to inform your healthcare provider of all the drugs you’re taking. Some notable interactions include:

  • Antidepressants: In addition to MAO inhibitors like phenelzine and tranylcypromine, SSRIs such as sertraline or fluoxetine) and SNRIs such as venlafaxine or duloxetine, may interact with Adderall.
  • Blood pressure medications: Beta-blockers, like atenolol and metoprolol, as well as ACE inhibitors, such as lisinopril and enalapril, may have reduced efficacy when taking Adderall.
  • Acidifying agents: Vitamin C supplements and citric acid (found in citrus fruits) can decrease Adderall absorption.
  • Alkalinizing agents: Baking soda (sodium bicarbonate) and antacids, like omeprazole or esomeprazole, can increase Adderall absorption, potentially leading to higher blood levels and increased effects or side effects.

Always consult with a healthcare professional before starting or stopping Adderall or other medication if taking Adderall.

Madayis vs Adderall: overview

Drug classSchedule II stimulantSchedule II stimulant
Brand / generic statusBrand name for dextroamphetamine/
Brand name for amphetamine salts
Form(s) of the drugExtended-release capsules

Immediate release tablets

Extended-release capsules
Standard dosage12.5 mg, 25 mg, 37.5 mg, and 50 mg extended-release capsules
5 mg to 30 mg tablets

5 mg, 10 mg, 15 mg, 20 mg, 25 mg, and 30 mg capsules
Conditions treatedFDA-approved uses:

Off-label uses:
• Various sleeping disorders
FDA-approved uses:
• Narcolepsy

Off-label uses:
• Depression
• Anxiety
• Bipolar disorder
CostBrand-name Mydayis:
• $1200 for 100 capsules
Brand-name Adderall:
• $11.39 per 5 mg tablet
• $341.70 for a 30-day supply

Generic form (amphetamine salts):
• $19 for 30 days of 5 mg tablets
• $43.50 for 30 extended-release 5 mg pills
Side-effectsCommon side effects:
• Insomnia
• Decreased appetite
• Weight loss
• Dry mouth
• Elevated heart rate
• Anxiety
• Restlessness
• Agitation
• Emotional liability

Serious side-effects:
• Seizures
• Exacerbated heart problems
• Mental illness
• Delusional thought process
• Hallucination
• Disordered thinking and behavior
• Urinary-related symptoms
Common side-effects:
• Loss of appetite
• Weight loss
• Dry mouth
• Nausea
• Headache
• Fever
• Trouble sleeping

Serious side-effects:
• Signs of blood flow problems
• Behavior changes
• Uncontrolled movements
• Shortness of breath
• Irregular heartbeat
• Seizures
• Trouble speaking
Warnings for useContraindicated for:
• Kidney failure
• Monoamine oxidase inhibitor (MAOI) use
• Pregnancy or breastfeeding
• Antidepressants
• Those with substance abuse disorders
Drug interactions:
• Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs)
• Blood pressure medication
• Acid reflux medication
• Blood thinners
• Cold or allergy medication
• Opioid-based medications
• Seizure medication

Which medication treats ADHD better?

Mydayis and Adderall XR are both extended-release medications containing active ingredients like amphetamine sulfate to help treat symptoms of anxiety. Adderall is also available in an immediate-release version, and a provider can give you more information about the benefits of all 3.

Mydayis is the first mixed amphetamine salts formula that can improve ADHD symptoms for as long as 16 hours with only 1 daily dose. However, both medications have similar benefits for those struggling with ADHD. 

Both Adderall and Mydayis are Schedule II drugs, meaning they’re the stimulants with the highest risk of abuse and dependency. It’s important to note that Adderall and Mydayis shouldn’t be prescribed to those with a history of substance abuse, as there are additional options to treat ADHD that are less or non-addictive. A provider will speak to you about the pros and cons of each medication relative to your ADHD and can help you determine which medication is the most suitable for you. 

Find the right ADHD medication

If you’re struggling with symptoms of ADHD, FDA-approved prescription drugs like Adderall or Mydayis can be an effective treatment option. Find a provider for an online or in-person appointment on Klarity today to get your symptoms evaluated and receive proper treatment.

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