Vyvanse and Wellbutrin Together: Combination Guide, Benefits & How They Compare

Can you take Vyvanse and Wellbutrin together? Yes, in many cases. Providers sometimes prescribe this combination for people with both ADHD and depression, as Vyvanse addresses focus and attention while Wellbutrin improves mood. However, the combination increases the risk of certain side effects — including seizures, elevated blood pressure, and serotonin syndrome — and should only be used under close medical supervision.

Vyvanse vs. Wellbutrin as standalones: Vyvanse is a Schedule II stimulant FDA-approved for ADHD. Wellbutrin is a non-stimulant antidepressant (NDRI) approved for depression — sometimes prescribed off-label for ADHD. They work differently: Vyvanse directly increases dopamine and norepinephrine release; Wellbutrin prevents their reuptake. For ADHD without depression, Vyvanse is generally more effective. For ADHD with co-occurring depression, the combination may offer benefits neither can achieve alone.

People with attention deficit hyperactivity disorder (ADHD) are almost three times more likely to develop depression than the general population. Treating both conditions is important, but are there effective treatment options that can simultaneously help treat ADHD and depression?

What is Vyvanse?

Vyvanse is a stimulant medication. It’s a prodrug — its active ingredient, lisdexamfetamine, is converted to dextroamphetamine in the body. As a stimulant, Vyvanse increases the amount of norepinephrine and dopamine in the brain, improving alertness, concentration, and impulse control. Like all stimulant medications, Vyvanse is a federally-controlled substance due to its addictive nature and risk of dependence.

What is Wellbutrin?

Wellbutrin (bupropion) is an atypical antidepressant — an NDRI that prevents norepinephrine and dopamine from being reabsorbed into brain cells. So there’s more of each available for the brain to use. This leads to a more balanced mood and improved symptoms of depression. Unlike Vyvanse, Wellbutrin is not a controlled substance and does not carry the same abuse risk.

Vyvanse vs. Wellbutrin: which is better for ADHD?

For ADHD specifically, stimulants like Vyvanse are considered first-line treatment and are generally more effective at reducing inattention, hyperactivity, and impulsivity than non-stimulants. Wellbutrin is sometimes used off-label for ADHD, particularly in people who cannot tolerate stimulants or have a history of substance use disorder. Studies suggest Wellbutrin may reduce ADHD symptoms compared to placebo, but its effect is smaller than Vyvanse. If you have ADHD alone (without depression), Vyvanse is typically the stronger choice.

Can you take Vyvanse and Wellbutrin together?

If you have both ADHD and depression, your healthcare provider may prescribe these medications together. In general, you can take Vyvanse and Wellbutrin at the same time if it’s safe in your specific situation. The combination isn’t well studied, and some people don’t tolerate it well. Experts recommend providers prescribe this combination only on a case-by-case basis.

Benefits of taking Vyvanse and Wellbutrin together

• Vyvanse and Wellbutrin may be prescribed together to help treat ADHD and depression in people who have both conditions.
• The two medications may have complementary effects — Vyvanse can help improve focus and attention while Wellbutrin improves mood and reduces symptoms of depression.
• Both increase norepinephrine and dopamine through different mechanisms, creating a synergistic effect.

Risks of taking Vyvanse and Wellbutrin together

• Combining Wellbutrin with Vyvanse may increase the risk of side effects such as high blood pressure, heart palpitations, serotonin syndrome, and insomnia.
• Both medications can increase the risk of seizures, and combining them may further increase this risk.
• Taking Vyvanse and Wellbutrin together may increase the risk of drug dependence and abuse.
• Some people may experience an increased risk of suicidal thoughts or behaviors when taking Wellbutrin.

How to take Vyvanse and Wellbutrin together

Typically, if you’re prescribed Vyvanse and Wellbutrin together, you take each medication as you would if prescribed individually. Vyvanse comes in oral capsules and chewable tablets in 7 doses — 10 through 70 milligrams, usually started at 10mg daily. Wellbutrin XL starts at 150mg in the morning; the target dose is 300mg per day. Your healthcare provider will determine the right dose and schedule, and counsel you on potential side effects.

Potential side effects and cautions

Both medications share several overlapping side effects including decreased appetite, dizziness, dry mouth, trouble sleeping, nausea, and weight loss. Serious side effects for each include seizures and heart problems. Taking them together increases the risk of all of these. Watch for signs of serotonin syndrome — seizures, muscle twitching, stiff muscles, fast heartbeat, confusion, or diarrhea — and seek immediate medical care if any occur.

Drug interactions

Both Vyvanse and Wellbutrin interact with and shouldn’t be taken with monoamine oxidase inhibitors (MAOIs), antipsychotics, antihypertensives, and tricyclic antidepressants. Always inform your provider or pharmacist about all medications before starting this combination.

Key takeaway

If you’re struggling with symptoms of ADHD and depression, a qualified mental health professional can determine if you’re experiencing one or both disorders and the best treatment. Find a provider on Klarity Health today for a comprehensive evaluation and treatment plan that includes medication if needed.

Frequently asked questions

Vyvanse vs. Wellbutrin: which should I take for ADHD?

For ADHD, Vyvanse is generally more effective — it’s a first-line stimulant treatment. Wellbutrin may be preferred if you can’t tolerate stimulants, have a substance use history, or also have depression. Your provider will help determine the best fit based on your full health history.

What happens when someone with ADHD takes Wellbutrin?

Wellbutrin (bupropion) is sometimes prescribed off-label for ADHD. Studies suggest it may reduce ADHD symptoms compared to a placebo. Its effectiveness and side effects can vary by individual.

Is it okay to take Vyvanse and antidepressants?

Taking Vyvanse with certain antidepressants requires caution. MAOIs are contraindicated. SSRIs combined with Vyvanse may raise the risk of serotonin syndrome. Always consult a healthcare provider before combining Vyvanse with any antidepressant.

Can I take an SSRI, Wellbutrin, and Vyvanse at the same time?

Combining all three is generally not recommended due to higher risk of serotonin syndrome and other side effects. It should only be used if medically necessary and under close provider supervision.