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ADHD
21 min read
Written by Klarity Editorial Team
Published: Oct 31, 2022
Medically Reviewed by Dr. Zoe Russell
People with attention deficit hyperactivity disorder (ADHD) are almost three times more likely to develop depression than the general population. Treating both conditions is important, but are there effective treatment options that can simultaneously help treat ADHD and depression?
Vyvanse and Wellbutrin are two different medications that can work synergistically to treat symptoms of ADHD and other comorbid mood disorders, like depression. If you have ADHD and experience depression, this combination of medications might be right for you.
However, taking Vyvanse and Wellbutrin, either singly or together, isn’t recommended for everyone. In this post, Klarity discusses Vyvanse and Wellbutrin and how both can work together to help people with comorbid ADHD and depression symptoms. We also address situations where Vyvanse or Wellbutrin might not be right for you.
Want to talk to a medical provider about how Vyvanse and Wellbutrin interact but don’t have the time to wait weeks for an appointment?
Klarity makes it easy to book an appointment with a board-certified, fully licensed mental health provider who can help you find online ADHD treatment and online depression treatment.
Here’s how it works:
Schedule an appointment with an ADHD-trained mental health provider who can diagnose ADHD and depression and prescribe Vyvanse and Wellbutrin, if necessary, within 48 hours.
This article discusses suicide, suicidal ideation, and self-harm. If you or someone you know is experiencing suicidal thoughts or is in crisis, contact the Suicide Prevention Lifeline immediately at 800-273-8255.
Vyvanse is a central nervous system stimulant. The main ingredient in Vyvanse is lisdexamfetamine dimesylate. Once it hits your body’s GI tract, it is converted to an active ingredient—dextroamphetamine, a type of amphetamine used to treat attention deficit hyperactivity disorder.
As a stimulant medication, Vyvanse increases the amount of norepinephrine and dopamine in the brain. Norepinephrine is a neurotransmitter that stimulates the central nervous system, improving alertness, concentration, and cognition. Dopamine is a neurotransmitter whose function is crucial to the brain’s reward center. It is the “feel good” neurotransmitter.
As a result, Vyvanse produces feelings of euphoria and well-being in addition to helping improve concentration and attention span and reduce hyperactivity and impulsive behaviors. Because of Vyvanse’s effect on impulsive behavior, it is FDA-approved to treat binge-eating disorder.
However, as a stimulant medication, Vyvanse is a federally-controlled substance due to its addictive nature and risk of dependence, among other side effects. Sharing your prescription of Vyvanse or other medications of the same class with another person is illegal.
Vyvanse is available in oral capsules and chewable tablets. It is mostly prescribed in oral tablet form. Usually, patients start on a daily dose of 10mg by mouth and gradually increase the dosage if no interactions or reactions occur.
Vyvanse oral capsules are available in:
Vyvanse chewable tablets come in the following dosages:
Vyvanse treats symptoms of ADHD and moderate-to-mild binge eating disorder in patients older than six years of age. It is sometimes prescribed “off-label” for treatment-resistant depression.
The core symptoms of attention deficit hyperactivity disorder are inattention, hyperactivity, and impulsivity. For adults with ADHD, hyperactivity symptoms are less severe than inattentive or impulsive symptoms.
Inattentive Symptoms Include:
Impulsivity Symptoms Include:
Because Vyvanse helps control symptoms of impulsivity, it is FDA-approved to treat binge-eating disorder (BED).
The cost of Vyvanse will depend on your dosage, pharmacy, and insurance. On average, a 30-day supply of 70 mg capsules without insurance or a product coupon is roughly $15 a pill, or $460.55 a month. There are no less-expensive, generic versions of Vyvanse. However, like with other medications, manufacturer’s coupons are available for people without insurance, reducing costs.
Here are the common side effects drugs like Vyvanse have on the central nervous system.
Taking Vyvanse comes with the risk of more serious side effects, which are less common. These include:
Serotonin syndrome is a toxic build-up of serotonin that can be fatal. It occurs most often when starting a new medication that elevates serotonin levels or as a drug interaction between two medications that boost serotonin levels.
This condition occurs hours after taking a new medication or increasing the dose of your current medication. Symptoms include:
Vyvanse is classified as a Schedule II drug under the Controlled Substances Act due to its stimulant properties, potential for misuse, and very high risk for dependency. This is because it belongs to the amphetamine class of medications. Long-term use, misuse, or high dosage may increase this risk, so it’s crucial to take Vyvanse as prescribed and under close medical supervision.
Additionally, if Vyvanse is discontinued suddenly, withdrawal symptoms can occur. Symptoms may vary in severity depending on the dosage and duration of use. The best way to stop taking Vyvanse is under the guidance of a healthcare provider.
Common withdrawal symptoms include:
Other medications frequently used to treat ADHD are also classified as Schedule II stimulants. The most frequently prescribed medications include:
It’s important to note that Vyvanse should always be taken under the guidance and supervision of a healthcare professional. Understanding the potential risks and side effects associated with this and similar medications can help individuals make informed decisions about their treatment options.
Serotonin syndrome is a rare but potentially fatal condition that occurs when there is too much serotonin in your body. Usually, serotonin toxicity occurs when patients increase their dose of medication or start a new medication that affects serotonin levels.
Serotonin syndrome usually occurs within a few hours of taking a higher dose of medication or starting other medications that elevate serotonin. Symptoms of serotonin include:
To prevent serotonin syndrome, patients prescribed Vyvanse should stop taking an monoamine oxidase inhibitor (MAOI) 14 days before starting stimulant medications like Vyvanse.
Common MAOIs are:
Always talk to your medical provider when stopping or starting other medications to avoid drug interactions.
Though there are no specific studies on Vyvanse and alcohol’s combined use, there have been studies on amphetamines, a similar drug, and alcohol. Mixing amphetamines and alcohol raises heart rate and blood pressure.
CNS stimulants can mask the effects of alcohol intoxication, which leads to people drinking more than they should — taking Vyvanse while drinking alcohol can lead to alcohol poisoning and injuries associated with drunkenness, like falling.
Wellbutrin (bupropion) is a unique antidepressant medication. It is an NDRI or norepinephrine-dopamine reuptake inhibitor. Like other antidepressant medication, this medication is FDA-approved to treat major depressive disorder (MDD) and seasonal affective disorder (SAD) and is prescribed to help with smoking cessation and weight loss.
Like Vyvanse, taking Wellbutrin elevates levels of dopamine and norepinephrine. Dopamine is responsible for feelings of well-being and is a vital part of the brain’s reward center. Norepinephrine excites the central nervous system and affects attention, concentration, and cognition.
Wellbutrin is available in two types of modified-release oral tablets—controlled release (Wellbutrin XL) or sustained release (Wellbutrin SR). Both Wellbutrin XL and Wellbutrin SR are considered “extended release.” Both are intended as a daily dose.
When you speak with your Klarity medical provider, they’ll help determine which form and dosage are best for you.
Oral tablet, sustained release (Wellbutrin SR):
Oral tablet, controlled-release (Wellbutrin XL):
Wellbutrin, Wellbutrin XL, and Wellbutrin SR are primarily prescribed to treat depression symptoms. In addition to treating depressive disorders, Wellbutrin is FDA-approved as a smoking cessation aid.
The cost of Wellbutrin XL and Wellbutrin SR will depend on your dosage, pharmacy, and insurance. A 30-day supply of Wellbutrin — 30 tablets — costs about $86.62, or $2.89 per pill. Health insurance will drastically reduce the cost of Wellbutrin. If you do not have health insurance, there are coupons and copay assistance programs available to reduce the costs of Wellbutrin.
All antidepressants carry some risk of side effects. Common side effects of Wellbutrin XL and SR include:
These side effects are often minor and disappear after a few days or weeks. However, if the above side effects persist over a few weeks, worsen, and interfere with your daily functioning, then talk to your medical provider about stopping or reducing the dosage.
Wellbutrin XL and SR can cause more serious side effects in a small percentage of Wellbutrin users. If prescribed Wellbutrin, monitor for the following side effects:
People prone to seizures, whether due to medication, a seizure disorder, or injury, must disclose this to their medical providers before taking Wellbutrin. 0.1% – 0.4% of Wellbutrin users experience seizures or an increased risk of having a seizure. This is especially true with alcohol use.
Unlike SSRIs, Wellbutrin does not have widely reported sexual side effects.
Wellbutrin can affect your weight and appetite, causing weight loss or weight gain. Be sure to disclose any history of eating disorders with your medical provider before taking Wellbutrin.
Wellbutrin might not be right for people with liver and kidney issues due to the increased strain on these organs when metabolizing Wellbutrin. People with diabetes and bipolar mood disorder should also not take Wellbutrin.
Also, Wellbutrin should not be prescribed to those with bipolar disorder or schizophrenia, and it has a small risk of causing psychosis in some patients.
Serotonin Syndrome
Though Wellbutrin primarily prevents the reuptake of norepinephrine and dopamine, which elevates the base levels of the two neurotransmitters, it also boosts serotonin to a lesser extent.
Because of this, Wellbutrin should not be taken with other medications that increase serotonin levels, including SSRIs and MAOIs.
Common MAOIs include:
Common SSRIs include:
Boxed warning
All antidepressants come with a black box warning from the FDA. In placebo-controlled trials of antidepressants, researchers saw an increase in suicidal thoughts and ideation among children and adolescents taking antidepressants compared to the placebo group.
These findings have not been replicated in adults. However, it’s important for people taking antidepressants to monitor for sudden mood, thoughts, and behavior changes. If these are experienced, contact your healthcare provider immediately.
Though they use different mechanisms, Vyvanse and Wellbutrin increase the available amounts of norepinephrine and dopamine in the brain. Because of this, Vyvanse and Wellbutrin have a synergistic effect when used to treat ADHD and depression.
Attention deficit hyperactivity disorder is often comorbid with other mental health conditions, including many varieties of depression, like seasonal affective disorder. These medications might be suitable for people with ADHD who have comorbid depression. However, taking the two medicines together increases the risk of certain side effects, such as seizures or negative drug interactions.
Here’s a breakdown of the potential benefits and drawbacks:
Benefits
Risks
Klarity has helped more than 30,000 people find diagnoses and treatment for various mental health issues — including ADHD and depression. Our novel telehealth service marketplace makes finding online ADHD and depression treatment affordable, fast, and convenient.
So, if you are curious about trying Vyvanse and Wellbutrin together to manage ADHD and depression symptoms, book an appointment on Klarity. Here’s why:
Klarity is fast: We will get you a virtual appointment with a licensed healthcare provider in your state within 48 hours.
Klarity is convenient: Meet with a provider anywhere you have cell service or WiFi — we put the doctor’s office in your pocket.
Schedule an appointment today to get started.
Sources
Carl Sherman. “Is It ADHD, Depression, or Both?” ADDitude. https://www.additudemag.com/adhd-and-depression-symptoms-treatment/
“Drug interactions between bupropion/naltrexone and Vyvanse.” Drugs. https://www.drugs.com/drug-interactions/bupropion-naltrexone-with-vyvanse-3559-0-1475-2533.html
“Bupropion (Oral Route) – Mayo Clinic”
https://www.mayoclinic.org,https://www.mayoclinic.org/drugs-supplements/bupropion-oral-route/precautions/drg-20062478
Jacqueline Sinfield. “Using Wellbutrin for ADHD.” Very Well Mind. https://www.verywellmind.com/using-wellbutrin-for-adhd-4137671
Janice Rodden. “Wellbutrin.” ADDitude. https://www.additudemag.com/medication/wellbutrin/#:~:text=When%20prescribed%20for%20ADHD%20treatment,like%20Vyvanse%20or%20Adderall%20XR.
Renato P. Munhoz. “Serotonin syndrome induced by a combination of bupropion and SSRIs.” National Library of Medicine. https://pubmed.ncbi.nlm.nih.gov/15602102/
“Vyvanse: Dosage, side effects, alternatives and more – Medical News Today.”
https://www.medicalnewstoday.com,https://www.medicalnewstoday.com/articles/vyvanse#side-effects
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