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Polymyxin B sulfate and trimethoprim (the generic version of Polytrim) is an FDA-approved antibiotic eye drop used to treat surface ocular infections such as bacterial conjunctivitis and blepharoconjunctivitis caused by susceptible bacteria, including Staphylococcus aureus, Haemophilus influenzae, and Pseudomonas aeruginosa. While the brand-name Polytrim was discontinued in the U.S. as of June 11, 2025, generic versions remain available.
Interested in getting evaluated for a polymyxin B sulfate and trimethoprim prescription online? Connect with a licensed provider through Klarity Health and receive care in as little as 24 hours.* Providers will assess your symptoms and determine if polymyxin B sulfate and trimethoprim or another treatment is appropriate.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
You’re unique. And your needs are too. You deserve surface ocular infection treatment from a provider committed to you. That’s why you can find a surface ocular infection specialist on Klarity Health and access:
From an experienced, board-certified healthcare professional.
or in-person through treatment tailored to you**
Your information is private, secure, and 100% HIPAA compliant.
*Your provider will discuss treatment options with you, which may or may not include medication.
Klarity Health connects you with experienced, licensed providers who specialize in the treatment of surface ocular infection. Select your state to see available providers.
Here’s how to receive a prescription on a telehealth platform if medically appropriate:
| Medication | Use Case | Side Effect Risk | Dosing Frequency | Notes |
| Polymyxin B + Trimethoprim | Mild–moderate bacterial conjunctivitis | Mostly local irritation | Every 3 hrs, up to 6× daily | Generic only; brand discontinued |
| Besifloxacin (Besivance) | Bacterial conjunctivitis | Headache, blurred vision, eye irritation | TID for 7 days | More convenient dosing; higher cost |
| Sulfacetamide + Prednisolone | Inflammatory ocular infections | Dizziness, eye discharge, eye irritation | QID | Useful for inflammatory manifestations of ocular infections; steroid risks apply, beware of sulfa allergy |
| Ofloxacin | Bacterial conjunctivitis, corneal ulcers | Eye irritation, dry eye syndrome, ocular edema | Up to QID | Available as a generic |
Polymyxin B/trimethoprim is a common, cost-effective option with broad coverage for surface ocular bacterial infections. Alternatives like besifloxacin may offer simpler dosing, while steroid-containing drops are reserved for cases with significant inflammation.
Read through stories from real patients who received treatment from healthcare providers on Klarity.
*Appointments are generally available within 24 hours. Free initial consultations are available only with select providers. Prescriptions, particularly for controlled substances, may require an in-person evaluation depending on the state of residence and current federal regulations.
The information provided in this article is for educational purposes only and should not be construed as medical advice. Always seek the guidance of a qualified healthcare professional with any questions or concerns you have regarding your health. Providers on Klarity Health are independent practitioners with clinical autonomy. Nothing in this article is intended to diagnose or treat any condition, including guaranteeing prescription medication of any kind or dosage. Not all providers on Klarity Health prescribe all medications, particularly medications that are controlled substances.
PO Box 5098 Redwood City, CA 94063
100 Broadway Street, Redwood City CA, 94063
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PO Box 5098 Redwood City, CA 94063
100 Broadway Street, Redwood City CA, 94063
