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Entresto (sacubitril/valsartan) is an FDA-approved prescription medication used to reduce the risk of cardiovascular death and hospitalization in individuals with chronic heart failure, including adults with reduced ejection fraction and pediatric patients aged 1 year and older.
Interested in getting evaluated for an Entresto prescription online? Connect with a licensed provider through Klarity Health and receive care in as little as 24 hours.* Providers will assess your symptoms and determine if Entresto or another treatment is appropriate.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
You’re unique. And your needs are too. You deserve heart failure treatment from a provider committed to you. That’s why you can find a heart failure specialist on Klarity Health and access:
From an experienced, board-certified healthcare professional.
or in-person through treatment tailored to you**
Your information is private, secure, and 100% HIPAA compliant.
*Your provider will discuss treatment options with you, which may or may not include medication.
Klarity Health connects you with experienced, licensed providers who specialize in the treatment of heart failure. Select your state to see available providers.
Getting started involves these steps:
When treating heart failure with reduced ejection fraction, here’s how Entresto compares to other commonly prescribed medications:
| Medication | Use Case | Key Advantage | Considerations |
| Entresto | HFrEF | Proven to reduce CV death and hospitalization more effectively than ACE inhibitors | May cause low blood pressure; requires ACE‑I washout |
| Enalapril (ACE‑I) | HFrEF, Hypertension | Generic and cost-effective | May cause cough; less effective at reducing mortality |
| Valsartan (ARB) | HFrEF, Hypertension | Lower risk of cough than ACE inhibitors | Not as effective alone as the Entresto combination |
| Metoprolol (Beta-blocker) | HFrEF, Arrhythmias | Reduces arrhythmias and mortality | May require slow titration; can worsen fatigue |
| Spironolactone (MRA) | HFrEF with fluid retention | Offers additional survival benefits | Requires monitoring for potassium and kidney function |
Entresto offers a unique dual-action approach (ARNi) that can lead to better outcomes in eligible patients compared to ACE inhibitors or ARBs alone.
Read through stories from real patients who received treatment from healthcare providers on Klarity.
*Appointments are generally available within 24 hours. Free initial consultations are available only with select providers. Prescriptions, particularly for controlled substances, may require an in-person evaluation depending on the state of residence and current federal regulations.
The information provided in this article is for educational purposes only and should not be construed as medical advice. Always seek the guidance of a qualified healthcare professional with any questions or concerns you have regarding your health. Providers on Klarity Health are independent practitioners with clinical autonomy. Nothing in this article is intended to diagnose or treat any condition, including guaranteeing prescription medication of any kind or dosage. Not all providers on Klarity Health prescribe all medications, particularly medications that are controlled substances.
PO Box 5098 Redwood City, CA 94063
100 Broadway Street, Redwood City CA, 94063
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PO Box 5098 Redwood City, CA 94063
100 Broadway Street, Redwood City CA, 94063
