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Entacapone is a prescription medication used as an adjunct to levodopa-carbidopa therapy in adults with Parkinson’s disease who experience “end-of-dose" motor fluctuations—when the effects of levodopa wear off before the next dose.
Through Klarity Health, U.S. patients can meet with licensed providers who assess whether entacapone is clinically appropriate. Providers will review your Parkinson’s history, current medications, prior dopamine response, and whether you experience wearing-off symptoms.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
You’re unique. And your needs are too. You deserve Parkinson’s disease treatment from a provider committed to you. That’s why you can find a Parkinson’s disease specialist on Klarity Health and access:
From an experienced, board-certified healthcare professional.
or in-person through treatment tailored to you**
Your information is private, secure, and 100% HIPAA compliant.
*Your provider will discuss treatment options with you, which may or may not include medication.
Klarity Health connects you with experienced, licensed providers who specialize in the treatment of Parkinson’s disease. Select your state to see available providers.
Using entacapone via klarity involves several steps:
Entacapone is intended for chronic use; consistency is important. Each bottle contains instructions on dosing—enhancing continuity across care teams. Telehealth makes management easy and ensures ongoing support.
Entacapone is a COMT (catechol-O-methyltransferase) inhibitor, used exclusively in combination with levodopa/carbidopa to enhance and extend the effect of levodopa in patients with Parkinson’s disease. It is most often compared with tolcapone, another COMT inhibitor, and other adjunctive Parkinson’s medications such as MAO-B inhibitors (e.g., selegiline, rasagiline) and dopamine agonists.
Compared to tolcapone, entacapone can be preferred in some cases due to its more favorable side effect profile. While tolcapone can inhibit COMT both centrally and peripherally, it carries a boxed warning for liver toxicity and requires frequent liver monitoring. Entacapone works peripherally and does not carry the same level of hepatic risks.Compared to MAO-B inhibitors, entacapone is more effective at increasing the bioavailability and duration of levodopa, but MAO-B inhibitors may offer additional neuroprotective benefits although this is under investigation. Entacapone is also more targeted—used only in patients who already take levodopa and experience “wearing-off” symptoms.
| Drug | Class | Primary Use | Pros | Cons |
| Entacapone | COMT inhibitor | Extends levodopa effect | Favorable side effect profile compared to tolcapone fewer CNS effects | Needs to be taken with each dose of levodopa/carbidopa |
| Tolcapone | COMT inhibitor | Similar to entacapone | Stronger effect | Hepatotoxicity risk |
| Rasagiline | MAO-B inhibitor | Adjunct or monotherapy | Once-daily dosing, potentially neuroprotective | Drug interactions, serotonin risk |
| Pramipexole | Dopamine agonist | Monotherapy or levodopa adjunct | Can be used in early PD | Associated with impulse control side effects |
In summary, entacapone has generally mild side effects, , evidence-based option for Parkinson’s patients who need help managing motor fluctuations.
Read through stories from real patients who received treatment from healthcare providers on Klarity.
*Appointments are generally available within 24 hours. Free initial consultations are available only with select providers. Prescriptions, particularly for controlled substances, may require an in-person evaluation depending on the state of residence and current federal regulations.
The information provided in this article is for educational purposes only and should not be construed as medical advice. Always seek the guidance of a qualified healthcare professional with any questions or concerns you have regarding your health. Providers on Klarity Health are independent practitioners with clinical autonomy. Nothing in this article is intended to diagnose or treat any condition, including guaranteeing prescription medication of any kind or dosage. Not all providers on Klarity Health prescribe all medications, particularly medications that are controlled substances.
PO Box 5098 Redwood City, CA 94063
100 Broadway Street, Redwood City CA, 94063
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PO Box 5098 Redwood City, CA 94063
100 Broadway Street, Redwood City CA, 94063
