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Doxylamine-pyridoxine is a combination prescription medication commonly used to treat nausea and vomiting during pregnancy (NVP), especially in the first trimester. Sold under the brand names Diclegis or Bonjesta, it combines two active ingredients: doxylamine, an antihistamine, and pyridoxine, a form of vitamin B6.
You can speak to a licensed provider on Klarity to review your symptoms and receive a prescription if appropriate. With virtual care, access to morning sickness relief can be quicker and more convenient than ever.
You’re unique. And your needs are too. You deserve online nausea and vomiting during pregnancy treatment from a provider committed to you. That’s why you can find a birth control specialist on Klarity Health and access:
From an experienced, board-certified healthcare professional.
or in-person through treatment tailored to you**
Your information is private, secure, and 100% HIPAA compliant.
*Your provider will discuss treatment options with you, which may or may not include medication.
Klarity Health connects you with experienced, licensed providers who specialize in nausea and vomiting during pregnancy. Select your state to see available providers.
If you’re experiencing persistent pregnancy-related nausea that hasn’t improved with lifestyle or dietary changes, getting a prescription for doxylamine-pyridoxine online is fast and convenient. Many telehealth platforms offer consultations specifically for pregnancy support and symptom management.
Steps to get a prescription online:
Some providers may suggest starting with vitamin B6 alone before prescribing this combination. Always consult with a licensed clinician before starting any new treatment during pregnancy.
Doxylamine-pyridoxine comes in two main forms: Diclegis (delayed-release), containing 10 milligrams of doxylamine and 10 milligrams of pyridoxine, and Bonjesta (extended-release), with a 20 milligram/20 milligram formulation. Both are prescription-only and taken orally. The dosing schedule is designed to maintain consistent blood levels and prevent nausea rather than treat it once it has started.
Typical dosing:
– Initial dose: 2 tablets of Diclegis at bedtime
– If needed: 1 tablet in the morning + 1 in the afternoon (max: 4 per day)
– Bonjesta: 1 extended-release tablet at bedtime (max: 2 per day)
– Diclegis
– Initial dose: 2 tablets of Diclegis at bedtime
– If needed: 1 tablet in the morning + 1 in the afternoon+2 at bedtime (max: 4 per day)
– Bonjesta:
– Initial Dose: 1 extended-release tablet at bedtime
– If needed: 1 tablet in the morning 2 at bedtime (max: 2 per day)
Administration tips:
– Take on an empty stomach with a full glass of water
– Start at bedtime to minimize next-day drowsiness
– Don’t crush or chew delayed-release tablets
– Avoid alcohol and sedating medications while using this treatment
– If you miss a dose, skip it and resume at your next scheduled time
The goal is to prevent nausea before it peaks, so sticking to a schedule is essential. Over-the-counter doxylamine or vitamin B6 shouldn’t be combined with this prescription without guidance.
Doxylamine-pyridoxine is well tolerated by most patients, especially when started at a low dose and gradually adjusted. However, like all medications, it can cause side effects. The most common is drowsiness, due to the sedating nature of doxylamine.
Common side effects include:
– Sleepiness or sedation
– Dry mouth
– Dizziness or lightheadedness
– Constipation
– Blurred vision
Less common but serious side effects:
– Allergic reactions (swelling, rash, trouble breathing)
– Confusion or vertigo in rare cases
– Rapid heart rate or palpitations
– Difficulty urinating
Warnings and precautions:
– Not recommended with other central nervous system depressants
– Shouldn’t be used while driving or operating machinery until you know how it affects you
– May worsen symptoms in patients with asthma, glaucoma, or urinary issues
– Long-term use is not generally necessary or recommended
Report any concerning symptoms to your provider, and avoid combining this medication with other antihistamines, unless specifically advised.
Doxylamine-pyridoxine is only available by prescription and comes under two brand names: Diclegis and Bonjesta. Both options may be expensive without insurance, but the cost varies significantly depending on the brand, dosage, pharmacy, and insurance coverage. There are also generic versions available, which are often more affordable.
| Pharmacy | Diclegis (30 tablets) | Bonjesta (30 tablets) | Generic (30 tablets) |
| GoodRx (Discount) | $520 – $650 | $600 – $750 | $30 – $90 |
| Local Pharmacy | $500 – $700 | $580 – $720 | $40 – $100 |
| Mail-Order Pharmacy | $480 – $680 | $550 – $700 | $35 – $85 |
Ways to save on doxylamine-pyridoxine:
– Request the generic version if available
– Use GoodRx, SingleCare, or similar discount services
– Ask your provider if over-the-counter doxylamine and vitamin B6 may be an alternative
– Inquire about manufacturer coupons for Diclegis or Bonjesta
While the brand-name versions are more expensive, many patients are able to access relief through generic prescriptions or through cost-saving programs. Always compare pharmacy prices before filling your prescription
Doxylamine-pyridoxine is the first-line prescription treatment for nausea and vomiting during pregnancy (NVP), recommended by medical guidelines after lifestyle and dietary changes fail. However, other medications may be considered if symptoms are severe or unresponsive.
Comparison to other NVP treatments:
Why choose doxylamine-pyridoxine:
For women with mild to moderate NVP, doxylamine-pyridoxine strikes a balance between efficacy and safety. It’s often used before escalating to stronger medications with more potential risks.
Read through stories from real patients who received treatment from healthcare providers on Klarity.
*Appointments are generally available within 24 hours. Free initial consultations are available only with select providers. Prescriptions, particularly for controlled substances, may require an in-person evaluation depending on the state of residence and current federal regulations.
The information provided in this article is for educational purposes only and should not be construed as medical advice. Always seek the guidance of a qualified healthcare professional with any questions or concerns you have regarding your health. Providers on Klarity Health are independent practitioners with clinical autonomy. Nothing in this article is intended to diagnose or treat any condition, including guaranteeing prescription medication of any kind or dosage. Not all providers on Klarity Health prescribe all medications, particularly medications that are controlled substances.
PO Box 5098 Redwood City, CA 94063
100 Broadway Street, Redwood City CA, 94063
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PO Box 5098 Redwood City, CA 94063
100 Broadway Street, Redwood City CA, 94063
