Written by Klarity Editorial Team
Published: Jan 22, 2026

Living with a chronic condition like psoriasis means finding the right medication is only half the battle. The other half? Affording it month after month. As insurance plans change—whether you’re turning 26 and aging out of your parents’ coverage or switching employers—the financial impact can be jarring. With traditional pharmacies charging upwards of $200 for specialty medications like Otezla, while alternatives like Amazon Pharmacy offer the same prescription for as little as $13, patients are left wondering: why the massive price disparity, and how can I access more affordable options?
When you pick up a prescription, the price you pay isn’t just about the medication itself. It’s influenced by a complex web of factors—many of which operate behind the scenes.
Pharmacy Benefits Managers like Optum serve as intermediaries between insurance companies, drug manufacturers, and pharmacies. While they’re meant to negotiate lower prices, many patients find themselves paying more rather than less.
‘PBMs were originally created to help manage costs, but the system has evolved into something that often prioritizes profit over patient access,’ explains Dr. Sarah Jenkins, a healthcare policy expert. ‘This is especially true for specialty medications like those used to treat psoriasis.’
One of the most vulnerable moments in your healthcare journey occurs during insurance transitions. Whether aging out of a parent’s plan at 26 or switching employers, these changes can cause dramatic price increases virtually overnight.
A recent survey found that 68% of patients experienced price increases after changing insurance plans, with specialty medications seeing the most dramatic jumps—sometimes by hundreds of dollars per refill.
Let’s break down the actual cost differences between pharmacy options for a medication like Otezla, commonly prescribed for psoriasis:
| Pharmacy Option | Average Monthly Cost Without Insurance | With Typical Insurance | With Copay Card |
|---|---|---|---|
| Traditional Pharmacy | $3,400+ | $200-$300 | $0-$50 |
| Specialty Pharmacy | $3,400+ | $150-$250 | $0-$50 |
| Amazon Pharmacy | $3,400+ | $13-$100 | Often eligible |
| Klarity Health Pharmacy Network | Varies | Transparent pricing | Assistance available |
The disparity is striking—and it’s driving many patients to explore alternatives to traditional pharmacy models.
Manufacturer copay cards can be lifesavers for patients on specialty medications, but they come with complexities.
Copay assistance programs, offered by drug manufacturers, help cover out-of-pocket expenses for eligible patients. For Otezla, the manufacturer offers a program that can reduce costs to as little as $0 for commercially insured patients.
However, there are important limitations:
Interestingly, some alternative pharmacies—including Amazon Pharmacy—accept manufacturer copay cards while offering lower base pricing. This creates a potential ‘best of both worlds’ scenario for patients who know how to navigate the system.
While price is a major factor, some patients express concerns about sharing health information with large tech companies. It’s worth noting that all pharmacies—including Amazon Pharmacy—are bound by HIPAA regulations protecting your medical information.
However, reading privacy policies carefully and understanding data use practices remains important when choosing any healthcare service provider.
‘When I turned 26 and lost my parents’ insurance, my Otezla prescription jumped from $25 to $290 per month,’ shares Michael, a psoriasis patient from Colorado. ‘Switching to Amazon Pharmacy and using the manufacturer’s copay card brought it down to $15. The difference has been life-changing—I don’t have to choose between treating my condition and paying rent.’
The dramatic price differences between pharmacy options highlight systemic issues in how medications are priced and distributed in the U.S. healthcare system. However, they also signal a shift toward more consumer-friendly options as alternative pharmacies and telehealth providers challenge traditional models.
Services like Klarity Health are part of this evolution, offering transparent pricing models and connecting patients with providers who understand the complexities of medication access and insurance navigation.
If you’re facing high costs for specialty medications like Otezla:
The price you pay for essential medications shouldn’t stand between you and effective treatment. By understanding your options and advocating for yourself, you can find more affordable access to the medications you need.
If you’re struggling to manage medication costs or need guidance navigating insurance transitions, Klarity Health’s providers can help. With expertise in chronic condition management and access to pharmacy networks with transparent pricing, we’re committed to making healthcare more accessible and affordable. Book a consultation today to explore your options.
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