Written by Alex Kilpatrick
Medically Reviewed by Klarity Editorial Team
Published: Jul 31, 2025
Are you wondering, “Does Aetna cover Zepbound?” Aetna might cover Zepbound (tirzepatide), but it depends on the particular Aetna plan and your circumstances.
During this guide, you’ll learn about eligibility criteria for Aetna coverage for Zepbound, how to know if your Aetna covers Zepbound, tips for improving your chances for approval, and more. Find a licensed provider on Klarity Health and get a telehealth appointment with a licensed healthcare provider within 24 hours.
Zepbound is an injectable prescription medication approved by the FDA for chronic weight management in adults with obesity or overweight adults with weight-related comorbidities.
The medication is also FDA-approved for moderate to severe obstructive sleep apnea (OSA) in adults with obesity. OSA is a sleep disorder where your breathing stops and starts repeatedly while you’re sleeping due to a blockage in your airway. This blockage leads you to wake up briefly throughout the night, which can lead to daytime sleepiness and other health issues.
Zepbound is part of a medication class called dual glucose-dependent insulinotropic polypeptide (GIP)/glucagon-like peptide-1 (GLP-1) receptor agonists. GIP is a hormone that stimulates insulin release from your pancreas when you consume glucose. GLP-1 is another hormone that stimulates insulin release, reduces blood sugar levels by suppressing glucagon secretion, and promotes feelings of fullness. Dual GIP/GLP-1 receptor agonists, such as Zepbound, combine the effects of GIP and GLP-1 receptor activation to better control blood sugar levels.
Zepbound works for weight loss by mimicking the effects of GIP and GLP-1, which regulate blood sugar and appetite. The medication slows down the emptying of your stomach, which makes you feel full longer and helps your body process sugar better, often leading to decreased food intake and weight loss.
Wondering if Aetna covers Zepbound? Aetna often covers Zepbound for weight loss or OSA, but some Aetna plans require prior authorization and that you meet certain eligibility criteria.
Aetna often requires prior authorization for Zepbound. Aetna coverage for Zepbound sometimes depends on meeting specific eligibility criteria related to body mass index (BMI), previous weight loss attempts, and previous participation in a comprehensive weight management program.
Here are the eligibility criteria for some Aetna plans’ coverage for Zepbound:
You sometimes need a baseline BMI of at least 30 kilograms per meters squared (kg/m2). Some Aetna plans might cover Zepbound if you have a BMI of at least 27 kg/m2, as long as you also have at least 1 weight-related comorbidity, such as type 2 diabetes or hypertension.
You sometimes need to show that you’ve participated in a comprehensive weight management program for at least 6 months. This program must include increased physical activity, a reduced-calorie diet, and behavioral modification.
Some Aetna plans require that you receive prior authorization for Zepbound. This means your licensed healthcare provider needs to submit documents that show you meet the eligibility criteria for Aetna coverage.
If you don’t meet these eligibility criteria, Aetna will sometimes cover other weight loss medications, such as Wegovy, as long as you meet specific criteria and receive prior authorization for those medications.
Here are a couple of the best ways to figure out whether your Aetna plan covers Zepbound:
Whether Aetna covers an online Zepbound prescription depends on your particular Aetna plan and whether Zepbound is considered medically necessary for you. You need to check your plan’s medication list or formulary. You typically need to get prior authorization for an online Zepbound prescription.
Aetna might deny Zepbound coverage for a few reasons:
Zepbound is only FDA-approved to treat chronic weight management and OSA. If you want to use Mounjaro for an off-label use, Aetna might deny coverage for you.
Aetna sometimes requires prior authorization for Zepbound, which means your prescribing provider needs to offer information about your medical history and treatment plan to Aetna for medication approval. If the prior authorization isn’t completed or the information doesn’t meet Aetna’s eligibility criteria, they can deny the claim.
Aetna might deny coverage for Zepbound if they don’t consider it medically necessary for you, particularly if there are equally effective and less expensive medications available.
Check the formulary for your specific Aetna plan. If Zepbound isn’t listed as a covered medication in your specific plan, Aetna is more likely to deny coverage.
Here are a few tips for improving your chances of Zepbound approval:
You sometimes need to meet eligibility criteria to get Aetna coverage of Zepbound. These eligibility criteria include a BMI of at least 30 or a BMI of at least 27 with weight-related comorbidities, such as hypertension, type 2 diabetes, OSA, or high cholesterol, and previous participation in a structured weight management program.
Many health insurance plans require step therapy. Step therapy is a strategy where you try other less expensive medications first before Zepbound. They want documentation that you’ve tried other medications first, which have either failed or resulted in harsh, intolerable side effects. Make sure your medical documents clearly state the medications you tried, doses, treatment duration, and reasons for inadequate response or discontinuation.
Offer evidence of the effectiveness of Zepbound, particularly if you’ve already started the medication. Your doctor’s medical records and lab results should also note your positive response to Zepbound.
If Aetna doesn’t cover Zepbound for you, you have several other options to consider:
There are several other medications to consider besides Zepbound, including Mounjaro, other GLP-1 receptor agonists, and other weight loss medications.
Medication | Details |
Mounjaro | Contains tirzepatide, the same active ingredient as Zepbound. |
GLP-1 Receptor Agonists | Includes Ozempic (semaglutide), Wegovy (semaglutide), and Saxenda (liraglutide). These are commonly prescribed for weight loss. |
Other Weight Loss Medications | – Phentermine – Qsymia (phentermine-topiramate) – Contrave (naltrexone-bupropion) – Xenical (orlistat) – Alli (orlistat) |
Your licensed healthcare provider might be able to appeal Aetna’s decision to deny coverage by offering documentation that proves the medical necessity of Zepbound for you. You can work with your provider to get documentation, including clinical notes and medical records, together to support your appeal.
Here’s what you need to do to get prior authorization from Aetna for Zepbound:
Here are some of the key takeaways:
Ready to get a prescription for Zepbound? With Klarity Health, getting a telehealth appointment with a licensed healthcare provider is fast, simple, and convenient. You can simply connect with a provider from your own home and receive quality medical care in as little as 24 hours. The Klarity Health platform connects you with board-certified healthcare providers who follow clinical guidelines.
*Appointments are generally available within 24 hours. Free initial consultations are available only with select providers. Prescriptions, particularly for controlled substances, may require an in-person evaluation depending on the state of residence and current federal regulations.
The information provided in this article is for educational purposes only and should not be construed as medical advice. Controlled substances may not be appropriate for all patients and any mention of these medications is for educational purposes only, not for marketing or encouraging self-diagnosis. Always seek the guidance of a qualified healthcare professional with any questions or concerns you have regarding your health. Providers on Klarity Health are independent practitioners with clinical autonomy. Nothing in this article is intended to diagnose or treat any condition, including guaranteeing prescription medication of any kind or dosage. Not all providers on Klarity Health prescribe all medications, particularly medications that are controlled substances.