Weight Loss
21 min read
Written by Nsisong Asanga
Published: May 15, 2024
Medically Reviewed by Dr. Sheelu Bhatnagar
Wegovy (semaglutide) is an injectable weight-loss medication that’s proven effective when used alongside a reduced-calorie diet and increased physical activity. In clinical trials, participants taking Wegovy lost up to 14.9% of their body weight or more in 68 weeks.
If you’re considering a Wegovy online prescription for weight management or weight loss, it’s a good idea to know what to expect while taking this medication. In this blog, you’ll learn more about Wegovy side effects and how to manage them.
If you have questions about Wegovy or its side effects, speak to a healthcare professional. Find a provider on Klarity Health today to learn more about Wegovy and its side effects.
Wegovy (semaglutide) is a prescription weight-loss medication made by Novo Nordisk. It’s U.S. Food and Drug Administration (FDA)-approved for adults with obesity (a body mass index [BMI] of 30 or more) or overweight (a BMI of 27 or more) with a weight-related medical condition. This includes high blood pressure, type 2 diabetes, or heart disease
It’s also approved to reduce the risk of major cardiovascular events, such as death, heart attack, or stroke, in adults with diagnosed heart disease and who have either obesity or are medically overweight.
Wegovy is FDA-approved for adolescents aged 12 and older with a BMI in the 95th percentile for their sex and age too. (This is one of the important differences between Wegovy and Ozempic, which both contain the active ingredient semaglutide. Ozempic is not FDA-approved for children, and should only be used by adults with type 2 diabetes to lower blood sugar.)
Wegovy is among the GLP-1 receptor agonist medications. This class of drugs mimics glucagon-like peptide-1 (GLP-1), a hormone in your body that’s released after eating to lower your blood sugar and delay stomach emptying. These effects help to decrease appetite, so you eat less and potentially lose weight.
Wegovy is meant for medically-supervised weight loss and should be paired with a reduced-calorie diet and increased physical activity for best results.
Like any medication, it can cause common and serious side effects. Some people should avoid it and no one should use it without medical supervision.
Side effects are the unwanted symptoms you could have when taking medication. While subcutaneous weight loss injections like Wegovy are considered safe, they can cause side effects that vary from pesky inconveniences to more serious issues.
Common side effects are those seen in up to 10% of participants. If seen in more than 10% of participants, the side effect is considered very common. In clinical trials for Wegovy, about 2 in 5 participants experienced common side effects. Common side effects tend to be mild or moderate in nature and can often be managed by lifestyle changes.
Serious side effects, such as low blood sugar, allergic reactions, and pancreatitis, are possible. In clinical trials, these side effects affected less than 2% of participants.
Your Wegovy experience will be unique. You may not experience side effects and if you do, they may not affect you the same way they affect other people. Also, medications like Wegovy can interact with other drugs, so be sure to discuss any other medications you’re taking with your healthcare provider before you start Wegovy.
Wegovy isn’t suitable for everyone. Factors like your medical history and current health conditions affect whether Wegovy’s benefits outweigh the risks in your case. Speak with a provider before starting a weight-loss medication to ensure it’s right for you.
The table below shows the percentage of clinical trial participants who experienced the 5 most common side effects of Wegovy.
Common side effect | % of placebo group affected | % of Wegovy group affected |
Nausea | 16% | 44% |
Diarrhea | 16% | 30% |
Vomiting | 6% | 24% |
Constipation | 11% | 24% |
Abdominal pain | 10% | 20% |
Other common Wegovy side effects include:
Though the list of possible side effects looks worrisome, most people don’t experience them. Side effects were the most common reason for people to drop out of the trial. Gastrointestinal (GI) side effects were experienced by 73% of participants taking Wegovy, compared to 47% of those taking a placebo. Likewise, 4.3% of people taking Wegovy had serious digestive system problems compared to 0.9% of those taking the placebo.
During one clinical trial, 84% of people taking Wegovy completed the trial. The remainder (16%) dropped out of the trial because of side effects, but so did 8% of those taking a placebo.
You’re more likely to experience side effects when you start taking Wegovy or when your dosage is increased. Most side effects are mild or moderate and usually go away after a week or two. Reach out to your provider if symptoms persist or interfere with your daily activities.
If you experience side effects from Wegovy or another weight loss medication, you may be able to manage them with diet and lifestyle changes. Here are some things you can try to reduce the common side effects of Wegovy.
OTC medication | Class | Common brand names | Symptoms addressed |
Ibuprofen | Non-steroidal anti-inflammatory (NSAID) | Advil, Midol, Motrin | Headaches, may relieve muscular ache related to abdominal distension |
Bismuth subsalicylate | Anti-nausea | Kaopectate, Pepto-Bismol | Nausea, vomiting |
Simethicone | Anti- gas | Gas-X | Gassiness, belching, burping |
Polyethylene glycol | Laxative | GoLytely, MiraLax, Glycolax, GoEvac | Constipation |
Calcium carbonate | Antacid | Tums, Alka-Seltzer, Rolaids | Heartburn |
Wegovy may not be the best medicine for you if your side effects persist despite treatment and lifestyle changes. Talk to your healthcare provider about your options. They’ll help you decide whether to stop Wegovy, lower your dose, or try another weight loss drug.
Real Wegovy users often share their experiences in reviews and online chat groups. Mild side effects like nausea, vomiting, and constipation are the leading concerns among Wegovy reviews. Yet a number of reviewers say they don’t experience side effects. Most agree that there’s no way to know what form your side effects will take until you start taking Wegovy.
People have also complained of changes in the way their face, neck, and buttocks look after taking Wegovy for a while. The changes in appearance are due to skin sagging after losing weight too fast. If you’re concerned about this, talk to a healthcare professional.
Serious side effects can occur when taking Wegovy. Serious side effects experienced in clinical trials include:
Other rare side effects seen in clinical trials are:
If you experience low blood sugar, consume a sugary drink or meal as soon as possible. For other serious side effects, contact your healthcare provider or call 911 immediately.
One of the best ways to avoid serious side effects of Wegovy is to have an open discussion with a healthcare professional. Choose a PharmD (doctor of pharmacy, aka pharmacist) who understands the side effects of Wegovy well, or whichever healthcare professional treats you for obesity or related health conditions right now. They can give you an honest opinion based on your situation and share all of the benefits and risks of taking Wegovy.
Remember, each piece of your medical history is important for your healthcare provider to know. They also need to understand your goals for using Wegovy and weight loss generally. This way they have the best opportunity to share tips for managing side effects of Wegovy that are most likely to help you.
Wegovy can interact with other drugs. Interactions may increase or decrease a medication’s effectiveness or cause side effects. Possible Wegovy drug interactions include:
Wegovy has a boxed warning for thyroid tumors and cancers such as medullary thyroid carcinoma. A boxed warning is the most serious warning from the FDA. It alerts doctors, patients, and the public about possible dangerous drug effects.
In animal studies of semaglutide (the active ingredient in Wegovy) there was a higher risk of thyroid cancer. However, thyroid cancer hasn’t been tied to Wegovy in humans. Since animal studies don’t always predict what happens in humans, it’s not certain whether Wegovy can increase thyroid cancer risk in humans. If you have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 (MEN 2), discuss taking Wegovy and your options with your healthcare provider.
Wegovy isn’t suitable for everyone. You should avoid Wegovy if you:
Most people feel better after losing weight with medications that contain semaglutide. But taking them isn’t always easy for everyone, because the side effects themselves can make you feel bad.
This might only be true when you first start taking semaglutide, but sometimes side effects like nausea, gas, burping, vomiting, or abdominal pain last.
And for some people, a lack of appetite can be a problem. Not wanting to eat can cause them social embarrassment, or make them feel weak, fatigued, and generally unwell.
The long-term side effects of using Wegovy can be both good and bad. Many users maintain significant weight loss over time. This can improve overall health, reduce the risk of heart disease, improve metabolic markers and type 2 diabetes, lower cholesterol levels and blood pressure, and otherwise improve obesity-related conditions.
But the news isn’t all good. Rapid weight loss from any method, including Wegovy, can increase the risk of gallstones or gallbladder disease. And while it’s rare, using Wegovy over time may increase the risk for pancreatitis, or worsen kidney function in some cases.
Regular monitoring by your healthcare provider is important to manage any risks associated with long-term use because the evidence still isn’t all in for any of the GLP-1 agonist medications.
When you stop taking Wegovy, you may gain some weight back, because its appetite-suppressing effects wear off. Your food cravings usually increase or come back, so it may be harder to maintain your weight loss.
If you’re using Wegovy off-label to also help manage type 2 diabetes, stopping it can cause your blood sugar levels to rise. You may also see some of the other benefits of taking it, like lower blood pressure and cholesterol levels, slip over time. You can help minimize this by keeping up with lifestyle changes like continuing to exercise and eating a healthy diet.
Wegovy (semaglutide) is a prescription weight loss medication that should be used as part of a medical weight loss program. Like any medication, it can cause side effects. Mild or moderate side effects usually improve or resolve within a few weeks of starting Wegovy or increasing your dose. They can often be managed with lifestyle and dietary adjustments and/or taking OTC remedies.
Wegovy may cause serious side effects that can be life-threatening. If you experience serious side effects, contact your healthcare provider or call 911 immediately.
Communicate with your healthcare provider about your experience. And keep your follow-up appointments while taking Wegovy, so your provider can track your progress and symptoms.
Find a weight loss provider on Klarity Health who can help you decide if Wegovy is the right weight loss medication for you. Appointments are available in as little as 24 hours. You never need insurance. And you won’t pay hidden fees.
*Appointments are generally available within 24 hours. Free initial consultations are available only with select providers. Prescriptions, particularly for controlled substances, may require an in-person evaluation depending on the state of residence and current federal regulations.
The information provided in this article is for educational purposes only and should not be construed as medical advice. Always seek the guidance of a qualified healthcare professional with any questions or concerns you have regarding your health. Providers on Klarity Health are independent practitioners with clinical autonomy. Nothing in this article is intended to diagnose or treat any condition, including guaranteeing prescription medication of any kind or dosage. Not all providers on Klarity Health prescribe all medications, particularly medications that are controlled substances.
If you’re having a mental health crisis or experiencing a psychiatric emergency, it’s crucial to seek immediate help from a mental healthcare professional, such as a psychiatrist, psychologist, or therapist. You can also call your local emergency services, visit your nearest emergency room, or contact a crisis hotline, such as the National Suicide Prevention Lifeline, by calling or texting 988 or dialing the Lifeline’s previous phone number, 1-800-273-TALK (1-800-273-8255) in the U.S.
Get free, credible health and wellness tips from Klarity
Subscribe to our blog for the latest insights and advice—totally free! No spam, and you can unsubscribe at any time.