Choosing the right ADHD medication can be daunting, especially with so many available choices. Though having a wide variety of available medications means more people can get treatment safely, finding the medication that works for you can quickly become complex—which is especially frustrating for someone already experiencing ADHD symptoms.
That’s why we’ve broken down the similarities, differences, and risks of two ADHD stimulant medications often prescribed to help people with ADHD manage their ADHD symptoms.
By the end of this post, you’ll have a clearer picture of each ADHD medication, including—
- Forms and doses
- Conditions treated
- The costs
- Side effects
- Any important drug warnings or interactions
If you are struggling with symptoms of ADHD, medications like Evekeo or Adderall could be the solution. Klarity connects patients with medical professionals for affordable online ADHD treatment, so you can receive personalized care and an effective prescription (if applicable) within 48 hours. Schedule an appointment to get matched with an ADHD specialist today.
|Drug Class||Schedule II stimulant||Schedule II stimulant|
|Brand / Generic Status||Brand name for amphetamine salts||Brand name for amphetamine salts|
|Form(s) of the Drug||Blue or gray scored immediate-release tablets||Immediate release tablets
|Standard Dosage||5mg and 10mg scored tablets||5mg to 30mg tablets
5 mg, 10 mg, 15 mg, 20 mg, 25 mg, and 30 mg capsules
|Conditions Treated||FDA-approved uses:|
• Bipolar disorder
|Cost||Brand-name Evekeo: |
• $400 to $450 for a one-month supply
• $50 to $150 with coupons or insurance
No generic form available for Rx
• $8 per 5mg tablet
• $237 for a 30-day supply
Generic form (amphetamine salts):
• $13 for 30 days of 5mg tablets
• $85 for 30 extended-release pills
• Visual disturbances
• Dry mouth
• Unpleasant taste
• Gastrointestinal disturbances
• Changes in weight
• Changes in libido
• Frequent or prolonged erections
• Peripheral vasculopathy
• Raynaud’s phenomenon
• Decreased appetite
• Weight loss
• Dry mouth
• Trouble sleeping
• Signs of blood flow problems
• Behavior changes
• Uncontrolled movements
• Shortness of breath
• Irregular heartbeat
• Trouble speaking
|Warnings For Use||Contraindications: |
• Heart or circulatory conditions
• History of drug abuse
• History of drug abuse
• SSRIs and SNRIs
• Blood pressure medication
• Acid reflux medication
• Blood thinners
• Cold or allergy medication
• Opioid-based medications
• Seizure medication
What is Evekeo?
Evekeo is a brand name for a medication that contains the active ingredient amphetamine sulfate. Amphetamine sulfate is a central nervous system stimulant medication that is used to treat ADHD and narcolepsy.
Evekeo works by increasing the levels of two important neurotransmitters in the brain, dopamine, and norepinephrine.
- Dopamine is involved in the brain’s reward and pleasure pathways and is important for motivation, attention, and focus.
- Norepinephrine is involved in the body’s fight-or-flight response and is important for attention, alertness, and concentration.
By increasing the levels of dopamine and norepinephrine in the brain, Evekeo can improve symptoms of ADHD, such as inattention, hyperactivity, and impulsivity. It can also improve symptoms of narcolepsy, such as excessive daytime sleepiness and sudden episodes of sleep.
Evekeo is similar to Adderall in that it contains both amphetamine and dextroamphetamine. The difference is that Evekeo contains 50% of each drug, whereas Adderall contains 75% dextroamphetamine and 25% amphetamine.
Evekeo, approved by the FDA in 2014, is a fast-acting, immediate-release (IR) ADHD stimulant.
Forms and Dosages
Evekeo comes in 5 mg and 10 mg blue or gray-scored tablets that can easily be broken into halves. Doses can be taken one to three times per day according to a doctor’s instructions. Adults typically start off with a 2.5 mg or 5 mg dose one to two times per day and increase the dosage as needed.
Evekeo is primarily used to treat ADHD (attention-deficit hyperactivity disorder), some forms of narcolepsy, and in some cases, obesity.
Because it hasn’t been on the market very long, you may be hard-pressed to find an insurance provider that covers Evekeo. Contact your insurance provider and ask them if they cover it or offer discounts for the medication.
For out-of-pocket costs, you’re potentially looking at $400 to $450 for a one-month supply of Evekeo. Online coupons or savings offered by your ADHD physician may help bring this medication down to between $50 and $150.
Like all medications, Evekeo can cause side effects, some of which are more common than others. Here are some of the most common side effects of Evekeo:
- Loss of appetite: Many people who take Evekeo experience decreased appetite, which can lead to weight loss or difficulty maintaining a healthy weight.
- Insomnia: Evekeo can interfere with sleep, making it difficult to fall asleep or stay asleep.
- Nervousness: Some people may feel jittery or anxious when taking Evekeo.
- Headache: Headaches are a common side effect of Evekeo and may be more likely to occur when starting the medication or increasing the dose.
- Dry mouth: Evekeo can cause dry mouth, which can be uncomfortable or lead to dental problems if left untreated.
- Nausea: Some people may experience nausea or vomiting when taking Evekeo.
- Dizziness: Evekeo can cause dizziness or lightheadedness, especially when standing up quickly.
- Increased heart rate: Evekeo is a stimulant medication that can increase heart rate and blood pressure, which can be concerning for people with preexisting heart or blood pressure conditions.
- Irritability: Some people may experience irritability or mood swings when taking Evekeo.
- Restlessness: Evekeo can cause restlessness or fidgeting.
It is important to note that not everyone will experience these side effects, and some people may experience side effects that are not listed here. If you experience any side effects while taking Evekeo, it is important to inform your healthcare provider.
Other side effects of Evekeo include but are not limited to:
- Visual disturbances
- Unpleasant taste
- Gastrointestinal disturbances
- Changes in weight
- Changes in libido
- Frequent or prolonged erections
- Peripheral vasculopathy
- Including Raynaud’s phenomenon
Warnings and Drug Interactions
Like any medication, Evekeo can interact with other drugs or cause adverse effects if not used properly. It is important to follow your healthcare provider’s instructions carefully and to inform them of any medications or supplements you are taking before starting Evekeo.
Here are some important drug warnings and interactions to be aware of when taking Evekeo:
Evekeo can increase heart rate, which can increase the risk of cardiovascular events such as heart attack and stroke. People with a history of heart disease, hypertension, or other cardiovascular conditions should use Evekeo with caution and under close medical supervision.
Evekeo can interact with other medications and supplements, including prescription drugs, over-the-counter medicines, and herbal supplements. Some of the medications that can interact with Evekeo include monoamine oxidase inhibitors (MAOIs), antacids, and certain antidepressants.
Taking Evekeo with these medications can increase the risk of adverse effects or reduce the effectiveness of either medication. Always inform your healthcare provider of all medications and supplements you are taking before starting Evekeo.
Substance abuse warning:
Evekeo is a Schedule II stimulant, indicating a risk of abuse and dependence. It should only be used under close medical supervision. Misusing Evekeo can lead to serious side effects such as heart problems, psychological disorders, or even death.
To avoid becoming dependent on Evekeo, it is crucial to follow the prescribed dosage and usage instructions. Do not exceed the recommended dose or take Evekeo more frequently than prescribed. Regular communication with your healthcare provider is vital to monitor the effectiveness of the medication and address any concerns or questions you may have.
Mental health risks:
Evekeo can worsen symptoms of mental health conditions such as anxiety, psychosis, and bipolar disorder. People with these conditions should use Evekeo with caution and under close medical supervision.
Pregnancy and breast-feeding:
Evekeo is not recommended for use during pregnancy or while breastfeeding, as it can be passed to the baby and may cause adverse effects.
Licensed providers on Klarity provide personalized mental health treatment. Find a provider that matches your needs and preferences.
What is Adderall?
Adderall is a brand name for a medication used to treat attention deficit hyperactivity disorder (ADHD) and treat narcolepsy. The active ingredients in Adderall and Evekeo are the same—amphetamine and dextroamphetamine.
Both are central nervous system stimulants that work by increasing the levels of dopamine and norepinephrine in the brain. Adderall’s ratio is 75% dextroamphetamine and 25% amphetamine.
Forms and Dosages
Adderall’s immediate-release (IR) tablets come in 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 20 mg, and 30 mg. The tablets can be taken one to two times per day and should not be taken after 12 PM to avoid experiencing issues with restlessness and sleep.
This ADHD medication is approved by the FDA to treat ADHD (attention-deficit hyperactivity disorder) and sleeping disorders like narcolepsy.
If you’re approved to take Adderall, you can expect the medication to run nearly $8 per day out-of-pocket. If you have health insurance, you likely pay anywhere from $10-$30 for the generic form. For more information on pricing for Adderall or its longer-lasting Adderall XR formula, contact your health insurance provider.
Like Evekeo, Adderall can cause side effects. Here are some common side effects of Adderall:
- Loss of appetite: Adderall can decrease appetite, which can lead to weight loss or difficulty maintaining a healthy weight.
- Insomnia: Adderall can interfere with sleep, making it difficult to fall asleep or stay asleep.
- Nervousness: Some people may feel jittery or anxious when taking Adderall.
- Headache: Headaches are a common side effect of Adderall and may be more likely to occur when starting the medication or increasing the dose.
- Dry mouth: Adderall can cause dry mouth, which can be uncomfortable or lead to dental problems if left untreated.
- Nausea: Some people may experience nausea or vomiting when taking Adderall.
- Dizziness: Adderall can cause dizziness or lightheadedness, especially when standing up quickly.
- Increased heart rate: Adderall is a stimulant that can increase heart rate and blood pressure, which can be concerning for people with preexisting heart or blood pressure conditions.
- Mood changes: Adderall can cause changes in mood, including irritability or mood swings.
- Restlessness: Adderall can cause restlessness or fidgeting.
Other Adderall side effects include:
- Irregular heartbeat
- Weight loss
- Eyesight instability
- Urinary tract infection
- Heart attack
Warnings and Drug Interactions
Adderall is classified as a Schedule II controlled substance, meaning it has a high potential for abuse and can lead to dependence. For this reason, it’s crucial to take Adderall exactly as prescribed by a healthcare professional, following the recommended dosage and schedule to ensure safe and responsible use. To minimize the risk of dependence, avoid increasing the dosage without medical guidance, and do not use Adderall for longer than prescribed.
Regularly communicate with your healthcare provider about the medication’s effectiveness and any concerns regarding dependence. It is essential to follow your healthcare provider’s instructions and seek their guidance for any adjustments or discontinuation plans to mitigate the potential risks associated with dependency.
Adderall increases blood pressure and heart rate because of its effect on norepinephrine. This can be a concern for people with pre-existing heart conditions.
Adderall can interact with other medications and supplements, which can increase the risk of adverse effects or reduce the effectiveness of either medication. It is important to inform your healthcare provider of all medications and supplements you are taking before starting Adderall.
- SSRI & SNRI drugs
- Blood pressure medication
- Acid reflux medication
- Blood thinners
- Cold or allergy medication
- Seizure medication
Substance abuse potential:
Adderall is a stimulant that has the potential for dependency and drug abuse. It is a controlled substance that should be used only as prescribed by your healthcare provider and under close medical supervision.
Mental health risks:
Adderall, like Evekeo, can make symptoms of certain mental health conditions worse. If you have anxiety, bipolar disorder, or a history of psychosis, it is important to use Adderall with caution.
Pregnancy and breastfeeding:
Adderall is not recommended for use during pregnancy or while breastfeeding.
Adderall vs Evekeo: Is Evekeo or Adderall Better for Your ADHD?
Both Evekeo and Adderall are effective medications for adults with ADHD. These medications are similar in chemical components but different in ratio. Because these medications contain the same ingredients, it’s best to speak with an ADHD physician who can effectively explain whether Evekeo or Adderall will be better for your specific condition.
Also, remember that budget may be a factor in this comparison—Evekeo is not available in generic form and is likely more expensive than Adderall.
How Klarity Helps You Find the Best ADHD Medication In 48 Hours or Less
If you need ADHD treatment fast and don’t know which treatment is right for you, book a virtual appointment on Klarity. We’ll connect you with a board-certified medical provider who can help you figure out what ADHD treatment is best for you. If appropriate, we’ll send the prescription to a pharmacy of your choice for you to pick up at your convenience—all in 48 hours.
How do you get started? It’s easy—
Schedule an apointment today to meet virtually with a board-certified mental health provider in your area and get treatment fast!