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fsaHSA & FSA accepted; best-value for top quality care
fsaSame-day mental health, weight loss, and primary care appointments available
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fsaNow accepting insurance

Same-day post-exposure prophylaxis (PEP) treatment online

If you’ve been exposed to HIV, prompt action is crucial. Post-exposure prophylaxis (PEP) is a time-sensitive treatment that can help prevent HIV infection if started within 72 hours. Klarity Health connects you with licensed providers for same-day online PEP consultations.

✓ Appointments available within 24 hours*
✓ Transparent, affordable pricing
✓ Cash pay & inruance accepted. HSA and FSA eligible

*Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.

a picture of a provider who can offer best treatment

*Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.

Online PEP treatment for you and about you

You’re unique. And your needs are too. You deserve online PEP treatment from a provider committed to you. That’s why you can find an online PEP treatment specialist on Klarity Health and access:

Online PEP assessment and treatment online in 24 hours*

Online PEP assessment and treatment online in 24 hours*

From an experienced, board-certified healthcare professional.

Online PEP medication prescribed online

Online PEP medication prescribed online

or in-person through treatment tailored to you**

Confidential, personalized care

Confidential, personalized care

Your information is private, secure, and 100% HIPAA compliant.

*Your provider will discuss treatment options with you, which may or may not include medication.

Book an appointment for the PEP treatment

Klarity Health connects you with experienced, licensed providers who specialize in the treatment of PEP. Select your state to see available providers.

Top-rated providers available for you

Amethyst Maxey, FNP-CAPRN
4.98
Amethyst Maxey, FNP-CAPRN
Specializes in Psychiatry, Mental Health
Sawyer Flandreau, FNP-BC
5.0
Sawyer Flandreau, FNP-BC
Specializes in Family Medicine, Mental Health
Melissa Tam, FNP-BC
5.0
Melissa Tam, FNP-BC
Specializes in Internal Medicine, Family Medicine
Derek Timbs, FNP-BC
4.96
Derek Timbs, FNP-BC
Specializes in Weight Loss, Preventive Medicine
Margaret Gallagher, PhD, FNP-BC
5.0
Margaret Gallagher, PhD, FNP-BC
Specializes in Weight Loss, Mental Health
Laurie Jean Foley, PMHNP-BC
5.0
Laurie Jean Foley, PMHNP-BC
Specializes in Weight Loss, Mental Health
Kate Graen, PA-C
4.96
Kate Graen, PA-C
Specializes in Psychiatry, Mental Health
Ernest Emery, AGACNP-BC
5.0
Ernest Emery, AGACNP-BC
Specializes in Psychiatry, Internal Medicine
Noussaiba Ayour, PA
5.0
Noussaiba Ayour, PA
Specializes in Urgent Care, Behavioral Medicine
Amethyst Maxey, FNP-CAPRN
4.98
Amethyst Maxey, FNP-CAPRN
Specializes in Psychiatry, Mental Health
Sawyer Flandreau, FNP-BC
5.0
Sawyer Flandreau, FNP-BC
Specializes in Family Medicine, Mental Health
Melissa Tam, FNP-BC
5.0
Melissa Tam, FNP-BC
Specializes in Internal Medicine, Family Medicine
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Derek Timbs, FNP-BC
4.96
Derek Timbs, FNP-BC
Specializes in Weight Loss, Preventive Medicine
Margaret Gallagher, PhD, FNP-BC
5.0
Margaret Gallagher, PhD, FNP-BC
Specializes in Weight Loss, Mental Health
Laurie Jean Foley, PMHNP-BC
5.0
Laurie Jean Foley, PMHNP-BC
Specializes in Weight Loss, Mental Health
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Kate Graen, PA-C
4.96
Kate Graen, PA-C
Specializes in Psychiatry, Mental Health
Ernest Emery, AGACNP-BC
5.0
Ernest Emery, AGACNP-BC
Specializes in Psychiatry, Internal Medicine
Noussaiba Ayour, PA
5.0
Noussaiba Ayour, PA
Specializes in Urgent Care, Behavioral Medicine
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Symptoms of acute HIV infection

PEP is a preventive treatment and does not cause symptoms. However, if PEP is not initiated promptly after potential HIV exposure, an individual may develop acute HIV infection. Symptoms typically appear 2 to 4 weeks post-exposure and can include:

  • Fever
  • Fatigue
  • Swollen lymph nodes
  • Sore throat
  • Rash
  • Muscle aches
  • Night sweats
  • Mouth ulcers

These symptoms are often nonspecific and can resemble other viral infections. Early identification and treatment are vital to prevent the progression of HIV.

a picture of a man feel painful
A picture of diagnosed test tube

How is PEP diagnosed?

Diagnosing the need for PEP involves several steps:

  1. Exposure assessment: A healthcare provider evaluates the nature of the exposure, considering factors such as:
  • Type of exposure (e.g., unprotected sex, needle stick)
  • Time since exposure (PEP must be started within 72 hours)
  • HIV status of the source (if known)

    2. HIV testing: An initial HIV test is conducted to ensure the individual is HIV-negative before starting PEP.

    3.Risk evaluation: The provider assesses the risk level based on exposure details to determine if PEP is warranted.

    4.Baseline laboratory tests: Tests to evaluate kidney and liver function may be performed to ensure safe administration of PEP medications.

    Prompt evaluation and initiation of PEP are essential for effectiveness.

What are the best PEP treatment options?

Post-exposure prophylaxis consists of a 28-day course of antiretroviral therapy (ART), recommended by the CDC. The most effective results come from starting treatment as soon as possible after exposure.

Standard regimen

The preferred regimen includes:

  • Truvada (emtricitabine 200 mg / tenofovir disoproxil fumarate 300 mg), taken once daily
  • Plus one of the following:
    • Isentress (raltegravir 400 mg), taken twice daily
    • Tivicay (dolutegravir 50 mg), taken once daily

These medications are selected for their high efficacy and tolerability. The choice of regimen may depend on potential drug interactions and individual health needs.

Alternative treatment options

If a person can’t tolerate the preferred regimen or has pre-existing health conditions, alternative combinations of nucleoside reverse transcriptase inhibitors (NRTIs) and integrase strand transfer inhibitors (INSTIs) may be used.

Considerations

  • Kidney function: Tenofovir may impact renal health, so providers will check kidney function before prescribing.
  • Hepatitis B: Truvada is active against hepatitis B; stopping it suddenly could reactivate the virus.
  • Pregnancy: PEP is considered safe in pregnancy with appropriate monitoring.
a picture of best treatment
a picture of medications

Common medications to treat PEP

PEP requires prescription-only medications. These antiretrovirals stop HIV from replicating in the body. Below are the common medications used:

1. Truvada (emtricitabine/tenofovir disoproxil umarate)

  • Class: NRTI combination
  • Dosing: 1 tablet daily
  • Common side effects: Nausea, headache, mild gastrointestinal issues
  • Monitoring: Kidney function should be monitored during use

2. Isentress (raltegravir)

  • Class: INSTI
  • Dosing: 400 mg twice daily
  • Common side effects: Headache, insomnia, fatigue
  • Considerations: Fewer drug interactions than other options

3. Tivicay (dolutegravir)

  • Class: INSTI
  • Dosing: 50 mg once daily
  • Common side effects: Gastrointestinal issues, insomnia
  • Considerations: Simple once-daily dosing may improve adherence

It’s essential to take these medications exactly as prescribed. Skipping doses may reduce effectiveness.

How Klarity Health works

  1. Find a provider and book an appointment in minutes

    1. Meet your provider online for care and a prescription if needed

      1. Pick up your medication at a pharmacy if prescribed

        1. Get 24×7 ongoing support. Book a follow-up anytime

          With Klarity Health, you’re in good company

          Read through stories from real patients who received treatment from healthcare providers on Klarity.

          Frequently asked questions about online PEP treatment

          *Appointments are generally available within 24 hours. Free initial consultations are available only with select providers. Prescriptions, particularly for controlled substances, may require an in-person evaluation depending on the state of residence and current federal regulations.

          The information provided in this article is for educational purposes only and should not be construed as medical advice. Always seek the guidance of a qualified healthcare professional with any questions or concerns you have regarding your health. Providers on Klarity Health are independent practitioners with clinical autonomy. Nothing in this article is intended to diagnose or treat any condition, including guaranteeing prescription medication of any kind or dosage.  Not all providers on Klarity Health prescribe all medications, particularly medications that are controlled substances.