Insurance acceptance varies by provider. Klarity is a marketplace platform and does not bill insurance directly.
Alprazolam, the generic version of Xanax, is one of the most commonly prescribed medications for anxiety and panic disorders.
Can alprazolam help you? Find an anxiety provider on Klarity Health and get an alprazolam prescription online if medically appropriate. Many providers have appointments available in as little as 24 hours.* Explore Klarity’s network of cash-pay and insurance-accepting providers.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
Insurance acceptance varies by provider. Klarity is a marketplace platform and does not bill insurance directly.
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Alprazolam is the active ingredient in, and the generic version of, the brand-name drug Xanax. The prescription drug was first approved by the U.S. Food and Drug Administration (FDA) in 1981 to treat anxiety and panic disorders. Both Xanax and alprazolam are available as an extended-release version (noted by ER) as well.
Alprazolam belongs to the class of drugs known as benzodiazepines, or “benzos” for short. Benzodiazepines are central nervous system (CNS) depressants that help slow down your brain activity, promoting a sense of relaxation and reducing symptoms of anxiety.
Alprazolam is FDA-approved to treat adults with generalized anxiety disorder and panic disorder, with or without agoraphobia (intense fear of situations or environments that make you feel trapped, helpless, or embarrassed). Healthcare providers may prescribe alprazolam off-label for insomnia, depression, premenstrual syndrome (PMS), tinnitus, movement disorders, and eating disorders.
Whatever alprazolam is prescribed for, it’s intended to be used on a short-term basis. Alprazolam is considered a Schedule IV controlled substance and carries a FDA boxed warning for the potential of abuse, misuse, and dependence.
Like other benzodiazepines, alprazolam works by targeting the brain’s GABA receptors. GABA stands for gamma-aminobutyric acid (GABA), which is a neurotransmitter that naturally calms you down. Alprazolam enhances these effects, which helps people with anxiety or panic disorders feel less anxious and more relaxed.
A review of 84 studies found that alprazolam was as effective or better than other benzodiazepines in treating anxiety, panic disorder, and depression. Its effects also kicked in faster than some other benzodiazepines.
Alprazolam is FDA-approved to treat:
• Generalized anxiety disorder (GAD) in adults
• Panic disorder in adults, with or without agoraphobia (intense fear or avoidance of places or situations that make you feel trapped, helpless, or embarrassed)
Alprazolam ER is FDA-approved to treat panic disorder panic disorder in adults with or without agoraphobia.
Healthcare providers may also prescribe alprazolam off-label for depression, insomnia, PMS, tinnitus, and eating and movement disorders.
To take alprazolam, you need a prescription from a licensed healthcare provider who can diagnose anxiety or panic disorder and determine if alprazolam is medically necessary for you. Licensed providers who can write prescriptions include medical doctors (MDs), physician assistants/associates (PAs), and nurse practitioners (NPs).
On Klarity Health, you can find a licensed, board-certified provider who can write you an alprazolam prescription online, if they decide it’s medically appropriate. Before prescribing alprazolam, your healthcare provider will review your personal medical history and list of current medications and supplements to determine if alprazolam will be safe for you to take.
If they prescribe you alprazolam online, you can fill your prescription at any pharmacy that carries alprazolam. Some states require at least one in-person visit before a provider can prescribe medication. Find online prescribing regulations for your state on the Center for Connected Health Policy website.
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Alprazolam is an oral medication that comes in standard and extended-release tablets. The dosage strengths of the standard version range from 0.25 milligrams to 2 milligrams. For alprazolam XR, the dosage strengths range from 0.5 milligrams to 3 milligrams.
For GAD, the recommended starting dosage is 0.25 or 0.5 milligrams, three times daily. If needed, your healthcare provider may have you increase your dose every 3 to 4 days until you find the lowest effective dose for you. The maximum dose of alprazolam for GAD is 4 milligrams daily.
For panic disorder, the recommended starting dosage is 0.5 milligrams, three times daily. If needed, your healthcare provider may have you increase your dose in increments of no more than 1-milligram every 3 to 4 days until you find the lowest effective dose for you. The maximum dose of alprazolam for panic disorder is 10 milligrams daily, although it typically ranges from 5 to 6 milligrams.
If you are taking alprazolam ER for panic disorder, the recommended starting dosage is 0.5 or 1 milligrams, once daily in the morning. If needed, your healthcare provider may have you increase your dose in increments of no more than 1-milligram every 3 to 4 days until you find the lowest effective dose for you. The recommended total daily dose of alprazolam ER for panic disorder is 3 to 6 milligrams.
Alprazolam tablets should be swallowed whole. The medication should be stored at room temperature away from light.
When your treatment with alprazolam is complete, your healthcare provider will advise you on how to slowly taper off your dose. They may recommend reducing your dosage strength by 0.5 milligrams every 3 days, or outline a slower tapering schedule. If you have any tablets left, keep them in the container, close it tightly, and throw it away.
The most common side effects of standard-release alprazolam include:
The side effects of alprazolam ER has a different list of side effects, which include:
While rare, alprazolam can cause serious side effects, the risk of which may be higher in people with depression. You should not drive or operate heavy machinery until you know how alprazolam affects you. Some people should not use alprazolam, including those who are pregnant or breastfeeding or anyone who uses strong cytochrome P450 3A (CYP3A) inhibitors (except ritonavir).
Alprazolam can interact with alcohol and other medications, including:
Combining alprazolam with these medications can lead to life-threatening side effects, including breathing problems. Alprazolam and alprazolam ER are Schedule IV controlled substances and both medications carry an FDA boxed warning due to their dangerous interactions with opioids and the potential risks for abuse, misuse, and dependence when taking benzodiazepines.
If you take alprazolam and have any side effects, work with your provider and consider reporting negative side effects to the FDA by visiting MedWatch or calling 1-800-FDA-1088.
As a generic medication, alprazolam and alprazolam ER are significantly more affordable than brand-name Xanax. The average cost of 90 tablets of alprazolam (about a 30-day supply) ranges from $19 to $62, according to drugs.com and with its discount. The average cost of 60 tablets of alprazolam ER, or 30 tablets, ranges from $57 to $143, also according to drugs.com and with its discount.
Xanax and Xanax ER, on the other hand, cost significantly more: between $595 and $1,665 for 100 tablets of Xanax, and between $667 and $1,638 for Xanax ER, also according to drugs.com and with its discount. The prices can vary depending on the dosage.
Most insurance plans cover generic alprazolam, making it more affordable. If you don’t have insurance or you pay cash for your prescription, you can lower the cost of alprazolam by using a drug discount card from sites like SingleCare, GoodRx, drugs.com, and WellRx.
The manufacturer of Xanax offers a Xanax Savings Card that can lower the cost of a 30-day supply of brand-name Xanax to as little as $4 for eligible individuals.
Alprazolam is one of the most commonly prescribed anxiety medications, but other options are available. Here’s how alprazolam compares to other treatment options:
All of these medications can cause side effects, some of which can be serious. Common possible side effects may include, but aren’t limited to, nausea, dizziness, insomnia, and changes in weight and energy levels. Ativan and Valium, like alprazolam, are controlled substances and may lead to dependence or abuse. Zoloft has a boxed warning for suicidal thoughts and behaviors. Each medication has its own risks and benefits.
The best way to find out which anxiety treatment or medication is best for you is to talk to an anxiety specialist.
Medication management is a common option for those exploring anxiety treatment. Licensed providers available through Klarity can help determine whether medication is appropriate and, if so, tailor treatment based on your symptoms, history, and needs.
Reviews from real patients who received treatment from healthcare providers on Klarity Health.
Klarity Health connects you with experienced, licensed providers who specialize in anxiety treatment. Select your state and insurance plan to see available providers.
*Appointments are generally available within 24 hours. Free initial consultations are available only with select providers. Prescriptions, particularly for controlled substances, may require an in-person evaluation depending on the state of residence and current federal regulations.
The information provided in this article is for educational purposes only and should not be construed as medical advice. Controlled substances may not be appropriate for all patients and any mention of these medications is for educational purposes only, not for marketing or encouraging self-diagnosis. Always seek the guidance of a qualified healthcare professional with any questions or concerns you have regarding your health. Providers on Klarity Health are independent practitioners with clinical autonomy. Nothing in this article is intended to diagnose or treat any condition, including guaranteeing prescription medication of any kind or dosage. Not all providers on Klarity Health prescribe all medications, particularly medications that are controlled substances.
If you’re having a mental health crisis or experiencing a psychiatric emergency, it’s crucial to seek immediate help from a mental healthcare professional, such as a psychiatrist, psychologist, or therapist. You can also call your local emergency services, visit your nearest emergency room, or contact a crisis hotline, such as the National Suicide Prevention Lifeline, by calling or texting 988 or dialing the Lifeline’s previous phone number, 1-800-273-TALK (1-800-273-8255) in the U.S.