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Accept major insurances and cash-payHSA & FSA accepted; best-value for top quality careSame-day mental health, weight loss, and primary care appointments availableAccept major insurances and cash-payPhendimetrazine is a prescription weight loss medication that works as an appetite suppressant. It’s typically prescribed short-term to help adults with obesity jumpstart weight loss when used alongside diet and exercise.
Interested in getting evaluated for a phendimetrazine prescription online? Connect with a licensed provider through Klarity Health and receive care in as little as 24 hours.* Providers will assess your symptoms and determine if phendimetrazine or another treatment is appropriate.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
You’re unique. And your needs are too. You deserve online weight loss treatment from a provider committed to you. That’s why you can find a weight loss specialist on Klarity Health and access:
From an experienced, board-certified healthcare professional.
or in-person through treatment tailored to you**
Your information is private, secure, and 100% HIPPA compliant.
*Your provider will discuss treatment options with you, which may or may not include medication.
Klarity Health connects you with experienced, licensed providers who specialize in the treatment of weight loss. Select your state to see available providers.
Getting phendimetrazine online is simple with telehealth platforms like Klarity Health. Here’s how it works:
No insurance is required, and appointments are fast, confidential, and affordable.
Phendimetrazine comes in two main forms:
• Immediate-release tablets (35 milligrams)
• Extended-release capsules (105 milligrams )
Typical dosing guidelines:
• Immediate-release: 1 tablet (35 milligrams) taken 2 or 3 times a day, 1 hour before meals.
• Extended-release: 1 capsule (105 milligrams) once daily, 30 to 60 minutes before breakfast
Your dose of immediate-release phendimetrazine should be based on how well it manages your symptoms. Your provider will try to get you to the lowest effective dose, which can be as little as half a tablet (17.5 milligrams) per dose (2 to 3 doses each day).
The maximum daily dose is 2 tablets 3 times a day.
The maximum daily dose of extended-release phendimetrazine is 1,105 milligram capsule per day.
Important tips for taking phendimetrazine:
• Do not crush, chew, or split extended-release capsules
• Take earlier in the day to avoid insomnia
• Do not exceed 210 mg per day (immediate-release)
• If you miss a dose, skip it; do not double up
• If you need to stop taking phendimetrazine, your doctor may gradually decrease your dose
Common side effects include:
• High blood pressure
• Fast or irregular heartbeat
• Chest pain or poor blood flow to the heart (ischemia)
• Heart valve problems (like leaking valves)
• Overstimulation
• Restlessness
• Insomnia (trouble sleeping)
• Agitation
• Flushing (warmth or redness in the face)
• Tremor (shaking)
• Sweating
• Dizziness
• Headache
• Blurred vision
• Dry mouth
• Nausea
• Stomach pain
• Diarrhea
• Constipation
• Frequent urination
• Painful urination (dysuria)
• Changes in sex drive (libido)
Severe side effects may include:
• A rare condition called pulmonary hypertension, which causes high pressure in the lungs, can strain the heart
• Psychotic state (such as hallucinations or delusions)
• Valvular heart disease
• Effect on the ability to engage in potentially hazardous tasks
• Withdrawal effects following prolonged high-dose administration
Phendimetrazine can interact with several medications and substances. It should not be taken with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping them, due to the risk of a dangerous spike in blood pressure. Drinking alcohol while taking phendimetrazine may lead to adverse reactions. It may also alter how your body responds to insulin or oral diabetes medications, and can reduce the effectiveness of drugs used to lower blood pressure, like adrenergic neuron blockers. Phendimetrazine is labeled a Schedule III controlled substance because of its risk of misuse and dependence.
According to Drugs.com, with its discount, the average retail price for phendimetrazine is:
| Form | Strength | Qty | Cost |
| Tablets | 35 mg | 90 | $10.79 |
| Capsules (ER) | 105 mg | 30 | $91.95 |
You can save up to 80% on your prescription with pharmacy discount programs through platforms like GoodRx, NeedyMeds, WellRx, and SingleCare.
Compared to other stimulant weight loss medications, phendimetrazine is similar in function to phentermine, benzphetamine (Didrex), and diethylpropion (Tenuate). These medications all act as appetite suppressants and are FDA-approved for short-term use in individuals with obesity or overweight with risk factors. Phendimetrazine is unique because it’s available in both immediate-release and extended-release forms, allowing for flexible dosing schedules. Like others in this class, it’s typically prescribed for just a few weeks due to the risk of dependence and potential side effects like insomnia, dry mouth, and elevated blood pressure.
Compared to newer weight loss medications like semaglutide (Ozempic, Wegovy), phendimetrazine usually works faster but is generally less effective for long-term weight management. Semaglutides usually have gradual weight loss, but are meant to be longer-term solutions. One clinical trial reported that semaglutide helps patients lose more weight over time,18.5% of their total starting body weight in 68 weeks. But this is only 0.39 pounds per week compared to the average 1.9 pounds per week typically seen with phendimetrazine. While phendimetrazine suppresses appetite by stimulating the central nervous system (CNS), semaglutide mimics the glucagon-like peptide-1 (GLP-1) hormone, which regulates appetite and blood sugar. Semaglutides can have side effects such as stomach or bowel problems.
Phendimetrazine also differs from glucagon-like peptide-1 (GLP-1) receptor agonists like liraglutide (Saxenda) and tirzepatide (Zepbound), which are also designed for longer-term use alongside diet and exercise. These medications not only reduce appetite but also improve blood sugar control, especially in patients with type 2 diabetes. They tend to have fewer stimulant-related side effects, but they do have their own side effects, like nausea and diarrhea. While GLP-1s are generally more effective for sustained weight loss, phendimetrazine may be considered for short-term jumpstarts or in patients who can’t tolerate GLP-1 therapy.
Read through stories from real patients who received treatment from healthcare providers on Klarity.
*Appointments are generally available within 24 hours. Free initial consultations are available only with select providers. Prescriptions, particularly for controlled substances, may require an in-person evaluation depending on the state of residence and current federal regulations.
The information provided in this article is for educational purposes only and should not be construed as medical advice. Controlled substances may not be appropriate for all patients and any mention of these medications is for educational purposes only, not for marketing or encouraging self-diagnosis. Always seek the guidance of a qualified healthcare professional with any questions or concerns you have regarding your health. Providers on Klarity Health are independent practitioners with clinical autonomy. Nothing in this article is intended to diagnose or treat any condition, including guaranteeing prescription medication of any kind or dosage. Not all providers on Klarity Health prescribe all medications, particularly medications that are controlled substances.
If you’re having a mental health crisis or experiencing a psychiatric emergency, it’s crucial to seek immediate help from a mental healthcare professional, such as a psychiatrist, psychologist, or therapist. You can also call your local emergency services, visit your nearest emergency room, or contact a crisis hotline, such as the National Suicide Prevention Lifeline, by calling or texting 988 or dialing the Lifeline’s previous phone number, 1-800-273-TALK (1-800-273-8255) in the U.S.