Silenor (Doxepin) and Tofranil (Imipramine) are tricyclic antidepressants used to treat major depressive disorder, with Silenor also prescribed for anxiety and off-label uses like chronic pain, while Tofranil is also used for off-label conditions like neuropathic pain and migraines. Both can cause side effects such as dry mouth, drowsiness, and mood changes, and have significant drug interactions. Costs vary: Silenor from $4.26 to $42.15/month, Tofranil from $12.22 to $53.60 for 90 tablets. Klarity Health offers online access to licensed providers for depression treatment, with prescriptions available after consultation.
Depression can be resistant to first-line treatments like SSRIs, leading many to explore alternative options such as tricyclic antidepressants. Klarity connects patients with licensed mental health providers who can diagnose and prescribe effective treatments online within 24 hours.
Yes, both are tricyclic antidepressants developed in the 1950s. They work by blocking the reuptake of neurotransmitters like serotonin and norepinephrine, which helps improve mood and reduce depression symptoms. Despite their similarities, they have different uses, side effects, and interaction profiles.
Tricyclics are nonselective antidepressants affecting multiple neurotransmitter receptors in the brain. They are often prescribed for treatment-resistant depression, anxiety, chronic pain, and off-label conditions. They may cause more side effects compared to newer antidepressants.
Primarily prescribed for major depressive disorder and anxiety. Off-label uses include chronic urticaria, neuropathic pain, migraine prevention, and IBS. Available in capsules, oral solution, and topical forms, with doses up to 300 mg daily.
FDA-approved for major depressive disorder, off-label for anxiety, neuropathic pain, migraine prevention, IBS, and chronic fatigue syndrome. Comes in tablets, capsules, and liquid, with typical doses from 10 to 200 mg daily.
Serious side effects include worsening depression, suicidal ideation, difficulty breathing, and allergic reactions. Common interactions involve medications like Cymbalta, Lexapro, and Zoloft.
It interacts with numerous drugs, including blood pressure meds and thyroid supplements. Side effects can be severe; prompt medical attention is necessary if they occur.
Silenor costs range from $4.26 to $42.15 monthly depending on dose and pharmacy. Tofranil costs from $12.22 to $53.60 for 90 tablets at 25 mg. Generic forms are available for both medications, potentially reducing expenses.
Both drugs have significant interaction profiles, with Silenor interacting with 661 drugs and Tofranil with 690, including major interactions with common antidepressants and blood thinners. Both carry a black box warning for increased suicide risk in young populations.
Serotonin syndrome is a rare but serious concern with overdose or interactions, characterized by agitation, hallucinations, and rapid heartbeat. Use during pregnancy and breastfeeding carries risks such as neonatal complications.
If you suspect treatment-resistant depression, Klarity offers online consultations with licensed providers to assess your needs and prescribe medications like Silenor or Tofranil if appropriate. Appointments can be booked within 24 hours, with free initial consultations available with select providers.
The content is educational and not a substitute for professional medical advice. If experiencing a psychiatric emergency or suicidal thoughts, contact the National Suicide Prevention Lifeline at 800-273-8255 or dial 988 immediately.
Silenor (Doxepin) has antihistamine properties and off-label uses like urticaria, while Tofranil (Imipramine) is mainly for depression and off-label for pain and migraines.
Yes, both are tricyclic antidepressants, affecting multiple neurotransmitter systems to treat depression and other off-label conditions.
Common side effects include dry mouth, dizziness, sedation, weight changes, and mood alterations. Serious risks include serotonin syndrome and suicidal thoughts.
Silenor interacts with 661 drugs, including major interactions with Cymbalta, Lexapro, and Zoloft. Tofranil interacts with 690 drugs, including similar antidepressants and blood thinners like Warfarin.
Silenor costs vary from $4.26 to $42.15 monthly depending on dose and pharmacy. Tofranil ranges from $12.22 to $53.60 for 90 tablets at 25 mg, with generic options available.
Through Klarity, patients can access licensed mental health providers online for diagnosis and prescriptions of antidepressants like Silenor or Tofranil. Appointments are available within 24 hours, with free initial consultations with select providers. Visit helloklarity.com to get started.
If you are considering antidepressant therapy for treatment-resistant depression, consult with a qualified healthcare provider. Klarity makes it easy to obtain personalized care and medication prescriptions online, ensuring you get the treatment you need promptly and safely.