Semaglutide's side effects are mostly mild and include gastrointestinal issues like nausea (44%), diarrhea (30%), vomiting, and abdominal pain. Serious risks, though rare, include pancreatitis, gallstones, kidney injury, and allergic reactions. Proper management and medical guidance help ensure safe treatment.
Semaglutide is a medication used for weight loss and managing type 2 diabetes. It works by mimicking a natural hormone called GLP-1, which helps regulate appetite, blood sugar, and cardiovascular health. It is available as Wegovy, Ozempic, Rybelsus, and compounded forms.
The most frequently reported side effects are gastrointestinal, affecting over 20% of trial participants. The top issues include nausea (44%), diarrhea (30%), vomiting, constipation, and abdominal pain. These are usually mild and tend to improve over time.
Less common, but still mild, side effects include indigestion, bloating, belching, and low blood sugar in diabetics. These occur in fewer than 9% of users.
Though infrequent, serious side effects may include:
Post-marketing reports have also noted cases of thyroid tumors, gastrointestinal issues, and kidney problems. Monitoring and medical supervision are essential.
To reduce side effects, follow your provider’s dosing instructions, start with lower doses, and increase gradually. Eating smaller, frequent meals, staying hydrated, and avoiding spicy or fatty foods help manage gastrointestinal symptoms.
If side effects persist or worsen, inform your healthcare provider promptly. They may adjust your dose or suggest supportive medications like antacids or anti-nausea drugs.
If you miss a dose within 5 days, take it as soon as possible. If more than 5 days have passed, skip the missed dose and resume your regular schedule. Do not double up doses to avoid increased side effects like nausea or hypoglycemia.
Individuals with a personal or family history of medullary thyroid cancer or MEN 2 syndrome should avoid semaglutide. Pregnant or breastfeeding women, and those with severe gastrointestinal issues, should also refrain from use.
Always discuss your medical history and any concerns with a qualified healthcare professional before starting semaglutide. Proper use and monitoring are key to safe and effective weight management.
If you're interested in safe, FDA-approved weight loss treatment, find a qualified provider on Klarity Health. Appointments are typically available within 24 hours, with personalized care from licensed professionals. Prescriptions can be provided online if appropriate, and treatment can start quickly and affordably.
Medical Disclaimer: This article is for educational purposes only and does not replace professional medical advice. Always consult your healthcare provider before starting or stopping any medication.