Doxepin and Amoxapine are tricyclic antidepressants used to treat depression, with distinct features: Doxepin treats anxiety and itching, while Amoxapine affects dopamine and is used for psychotic depression. Both have side effects and require a prescription.
Tricyclic antidepressants (TCAs) are among the oldest classes of medications for depression and anxiety. They work by blocking reuptake of neurotransmitters such as serotonin, norepinephrine, and in the case of Amoxapine, dopamine, to improve mood.
Both medications are prescribed to treat major depressive disorder. Doxepin is also used for anxiety and off-label for insomnia and dermatological itching, while Amoxapine is effective for depression with psychotic features.
Doxepin treats eczema-related itching and off-label chronic pain. Amoxapine may also be used for neuropathic pain and insomnia. Both medications are prescribed when first-line treatments are ineffective.
Doxepin blocks serotonin and norepinephrine reuptake, boosting these neurotransmitters. Amoxapine shares this but additionally blocks dopamine, making it suitable for depression with psychosis.
Both drugs can cause sedation, dry mouth, dizziness, weight changes, and gastrointestinal upset. Serious risks include serotonin syndrome, cardiac issues, and in elderly, falls or low blood pressure.
Interactions include other anticholinergic drugs, blood pressure meds, MAO inhibitors, and alcohol. Careful disclosure to healthcare providers is essential to avoid adverse effects.
Both medications carry risks of serotonin syndrome, especially when combined with other serotonergic drugs. Use during pregnancy is generally avoided; breastfeeding is considered safe for Amoxapine but not Doxepin.
This serious condition occurs with high serotonin levels, symptoms include agitation, confusion, increased heart rate, and muscle rigidity. Immediate medical attention is necessary if symptoms appear.
Klarity Health offers quick access to licensed providers who can diagnose and prescribe these medications. Appointments are available within 48 hours, with options for same-day care, accepting major insurances and FSA/HSA plans.
This content is educational and not medical advice. All medications require a licensed healthcare provider’s prescription. If experiencing a psychiatric emergency, contact local emergency services or hotlines such as 988.
Yes, both require a prescription from a licensed healthcare provider, due to potential serious side effects and interactions.
Yes, Klarity Health connects you with licensed professionals who can diagnose and prescribe Doxepin or Amoxapine within 48 hours online.
Doxepin primarily treats depression, anxiety, and itching, with less impact on dopamine. Amoxapine also treats psychotic depression due to dopamine effects and may have different side effect profiles.
Common side effects include sedation, dry mouth, dizziness, and gastrointestinal upset. Serious risks are serotonin syndrome, cardiac issues, and in elderly, falls or low blood pressure.