Dexedrine contains dextroamphetamine affecting dopamine and norepinephrine, while Adderall combines dextroamphetamine and amphetamine salts, targeting both CNS and PNS for broader effects. Effectiveness varies per individual.
Medically reviewed by Klarity Editorial Team. Both medications are central nervous system (CNS) stimulants approved for ADHD and narcolepsy. They help improve focus, alertness, and overall well-being. The primary difference lies in their active ingredients and how they act in the body.
Dexedrine's active ingredient is dextroamphetamine sulfate, which increases dopamine and norepinephrine in the brain. Adderall contains a mixture of amphetamine salts, affecting both CNS and peripheral nervous system (PNS), and inhibits dopamine reuptake, enhancing motivation and attention.
Without insurance, monthly costs vary. Dexedrine brand costs around $2,212; generics are less expensive (up to $189.98 for extended-release). Adderall brand costs approximately $1,234; generics range from $21.39 to $828.93 depending on form and dosage.
Both medications are effective, but individual responses differ. Dexedrine is often considered stronger, but Adderall may better target core symptoms. Your provider can help determine which is suitable based on your response and tolerability.
Both can cause decreased appetite, trouble sleeping, dizziness, headaches. Dexedrine may cause tremors; Adderall may result in anxiety and urinary tract infections.
Serious effects include circulation issues, increased blood pressure, heart problems, psychiatric disturbances, serotonin syndrome. Use is contraindicated in patients with serious cardiac conditions.
Switching medications should always be done under medical supervision. Both drugs have high potential for misuse and dependence. Patients with heart disease or psychiatric history should consult their healthcare provider before use.
If you're considering Dexedrine or Adderall, consult a licensed healthcare provider. On Klarity, you can get a diagnosis and prescription within 24 hours. Our providers offer safe, personalized treatment plans.
The content is educational and not a substitute for professional medical advice. In case of psychiatric emergencies, seek immediate help from healthcare professionals or call emergency services.
Find a provider on Klarity today for ADHD diagnosis and medication management. We accept many insurances and offer same-day appointments. For urgent mental health needs, contact crisis hotlines like 988 or 1-800-273-TALK.